| Cardiovascular and plasma catecholamine response to static exercise in normotensive blacks and whites. | |
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MedLine Citation:
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PMID: 9395595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The objectives of the present study were (1) to evaluate the pressor response to an isometric handgrip exercise in normotensive black and white males; (2) to measure plasma catecholamine levels pre- and post-exercise, as an index of sympathetic nervous system activity; and (3) to quantify the pressor response to bolus intravenous injections of phenylephrine (an alpha-specific agonist). METHODS: Cardiovascular and catecholamine responses to an isometric handgrip exercise (3 minutes at 30% MVC) were measured in 15 normotensive blacks and whites. In another phase of the study, pressor responses to bolus injections of phenylephrine were assessed to evaluate alpha-adrenergic sensitivity. RESULTS: The blood pressure in the blacks increased from 119/69 to 160/120 mm HG during isometric exercise, while in the whites it increased from 118/67 to 153/110 mm HG. The blacks exhibited a greater diastolic blood pressure reactivity, as evidenced by a significant race x time interaction (p < 0.05). The heart rate responses were not significantly different between the two groups. The plasma levels of norepinephrine were similar at rest, but were 25% lower in the blacks than in the whites following isometric exercise (p < 0.01). Black subjects also demonstrated an increased pressor response to intravenous injections of phenylephrine at rest (p < 0.05). CONCLUSIONS: The enhanced vascular sensitivity to norepinephrine may have contributed to the greater exercise pressor response in the blacks. |
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Authors:
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W J Duey; D R Bassett; A J Walker; D J Torok; E T Howley; D Ely; M O Pease |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ethnicity & health Volume: 2 ISSN: 1355-7858 ISO Abbreviation: Ethn Health Publication Date: 1997 Mar-Jun |
Date Detail:
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Created Date: 1997-12-31 Completed Date: 1997-12-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9608374 Medline TA: Ethn Health Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 127-36 Citation Subset: IM |
Affiliation:
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Exercise Science Unit, University of Tennessee-Knoxville, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Adult African Continental Ancestry Group* Blood Pressure / physiology* Epinephrine / blood* European Continental Ancestry Group* Exercise / physiology* Hand Strength Heart Rate / physiology* Humans Injections, Intravenous Male Norepinephrine / blood* Phenylephrine / pharmacology Reference Values Sympathetic Nervous System / physiology Vasoconstrictor Agents / blood* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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