Document Detail

Cardiovascular pathology possibly associated with ketamine/xylazine anesthesia in Dutch belted rabbits.
MedLine Citation:
PMID:  10331545     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: After myocardial necrosis and fibrosis was observed in five rabbits which had been anesthetized a variable number of times, the potential relationship of these lesions and anesthesia was evaluated in 35 other rabbits. METHODS: Anesthesia was induced by intramuscular administration of ketamine and xylazine followed by infusion of lactated Ringer's solution also containing ketamine and xylazine. Group A rabbits (n = 9) were subjected to multiple anesthesias and were evaluated by echocardiography, thoracic radiography, electrocardiography, determination of serum coronavirus titer, vitamin E concentration, and complete necropsy. Prior to a single acute procedure followed by necropsy, group B rabbits (n = 11) were evaluated by echocardiography only. Group C rabbits (n = 10) had never been anesthetized and were necropsied after euthanasia. Group D rabbits (n = 5) had intermediate anesthesia exposure history and were evaluated by echocardiography only. Myocardial fibrosis was scored semi-quantitatively on a scale of 0 to 4. RESULTS: Canine coronavirus test results were negative; hypovitaminosis E was evident, and fibrosis scores were significantly increased in group A, compared with group B or group C, rabbits. CONCLUSION: Etiologic differentials included alpha2-agonist-mediated coronary vasoconstriction with associated myocardial hypoperfusion, hypovitaminosis E and free radical injury, and other anesthetic-induced physiologic trespass.
R P Marini; X Li; N K Harpster; C Dangler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  49     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-25     Completed Date:  1999-06-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-60     Citation Subset:  IM    
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, USA.
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MeSH Terms
Anesthetics / adverse effects*
Antibodies, Viral / blood
Cardiovascular Diseases / chemically induced,  veterinary*
Coronavirus / immunology
Ketamine / adverse effects*
Myocarditis / chemically induced,  pathology,  veterinary
Myocardium / pathology
Organ Size
Specific Pathogen-Free Organisms
Vitamin E / blood
Xylazine / adverse effects*
Reg. No./Substance:
0/Anesthetics; 0/Antibodies, Viral; 1406-18-4/Vitamin E; 6740-88-1/Ketamine; 7361-61-7/Xylazine

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