Document Detail

Cardiovascular outcome of an angiotensin II receptor blocker, candesartan, in Japan.
MedLine Citation:
PMID:  20571611     Owner:  NLM     Status:  MEDLINE    
Candesartan cilexetil, an angiotensin II receptor blocker (ARB), was discovered in Japan in 1982. By the end of 2009, five randomized prospective clinical trials had been conducted in Japan. Herein, we examine the similarities and differences in the results with ARB reported from abroad and Japan. Candesartan reduced blood pressure of hypertensive patients to <140/90 mmHg with an average dose of 8 mg/day. In addition, candesartan reduced the incidence of cardiovascular events in a high-risk Japanese group of patients. From the analysis of the data obtained, candesartan-based treatment for hypertensive patients with and/or without cardiovascular diseases was effective in the Japanese population, as well as in subjects in Western countries.
H Suzuki; R Araki
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs of today (Barcelona, Spain : 1998)     Volume:  46     ISSN:  1699-3993     ISO Abbreviation:  Drugs Today     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-09-28     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101160518     Medline TA:  Drugs Today (Barc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-31     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved.
Department of Nephrology, School of Medicine, Faculty of Medicine, Saitama Medical University; Community Health Science Center, Saitama Medical School, Saitama, Japan.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / chemistry,  therapeutic use*
Antihypertensive Agents / therapeutic use*
Benzimidazoles / chemistry,  therapeutic use*
Cardiovascular Diseases / drug therapy
Clinical Trials as Topic
Heart Failure / drug therapy*
Hypertension / drug therapy
Tetrazoles / chemistry,  therapeutic use*
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; S8Q36MD2XX/candesartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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