| Cardiovascular outcome of an angiotensin II receptor blocker, candesartan, in Japan. | |
| | |
MedLine Citation:
|
PMID: 20571611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Candesartan cilexetil, an angiotensin II receptor blocker (ARB), was discovered in Japan in 1982. By the end of 2009, five randomized prospective clinical trials had been conducted in Japan. Herein, we examine the similarities and differences in the results with ARB reported from abroad and Japan. Candesartan reduced blood pressure of hypertensive patients to <140/90 mmHg with an average dose of 8 mg/day. In addition, candesartan reduced the incidence of cardiovascular events in a high-risk Japanese group of patients. From the analysis of the data obtained, candesartan-based treatment for hypertensive patients with and/or without cardiovascular diseases was effective in the Japanese population, as well as in subjects in Western countries. |
| | |
Authors:
|
H Suzuki; R Araki |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Drugs of today (Barcelona, Spain : 1998) Volume: 46 ISSN: 1699-3993 ISO Abbreviation: Drugs Today Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-23 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101160518 Medline TA: Drugs Today (Barc) Country: United States |
Other Details:
|
Languages: eng Pagination: 427-31 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved. |
Affiliation:
|
Department of Nephrology, School of Medicine, Faculty of Medicine, Saitama Medical University; Community Health Science Center, Saitama Medical School, Saitama, Japan. iromichi@saitama-med.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II Type 1 Receptor Blockers
/
chemistry,
therapeutic use* Antihypertensive Agents / therapeutic use* Benzimidazoles / chemistry, therapeutic use* Cardiovascular Diseases / drug therapy Clinical Trials as Topic Heart Failure / drug therapy* Humans Hypertension / drug therapy Japan Tetrazoles / chemistry, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 139481-59-7/candesartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxybutynin topical and transdermal formulations: An update.
Next Document: A report from the 4th Biennial Conference of the International Society of Bipolar Disorder (March 17...