Document Detail


Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis.
MedLine Citation:
PMID:  21905258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the presence of psoriatic arthritis (PsA) is associated with greater comorbidity, in particular cardiovascular morbidity, compared to psoriasis without arthritis.
METHODS: Six hundred eleven patients with PsA were recruited from the University of Toronto Psoriatic Arthritis Clinic and 449 psoriasis without arthritis patients were recruited from the University of Toronto Psoriasis Cohort. The clinical database was used to identify the prevalence of cardiovascular and other comorbidities in both PsA and psoriasis without arthritis patients. Univariate and multivariate logistic regression analyses were conducted to estimate odds ratios (ORs), comparing the odds of ever having a given comorbid disease in PsA patients with those in psoriasis without arthritis patients. Covariates included age, sex, education, smoking status, severity and duration of psoriasis, medication status, and other comorbidities.
RESULTS: The prevalence of hypertension, obesity, hyperlipidemia, type 2 diabetes mellitus, and at least 1 cardiovascular event in PsA patients was 37.1%, 30.0%, 20.7%, 12.0%, and 8.2%, respectively. This was significantly higher than in psoriasis without arthritis patients, with unadjusted ORs ranging from 1.54 to 2.59. In the multivariate analyses, hypertension remained significantly elevated (adjusted OR 2.17). PsA was also significantly associated with infections not treated with antibiotics (presumably viral), neurologic conditions, gastrointestinal disorders, and liver disease (adjusted ORs 2.83, 4.76, 21.53, and 7.74, respectively). Infections treated with antibiotics and depression/anxiety were relatively common in PsA, with a prevalence of 30.5% and 20.7%, respectively. However, this was not significantly different from psoriasis without arthritis after multivariate adjustments.
CONCLUSION: The results suggest that inflammatory joint disease may play a role in both cardiovascular and noncardiovascular morbidity in PsA.
Authors:
Janice A Husted; Arane Thavaneswaran; Vinod Chandran; Lihi Eder; Cheryl F Rosen; Richard J Cook; Dafna D Gladman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis care & research     Volume:  63     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-30     Completed Date:  2012-01-17     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1729-35     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Affiliation:
University of Waterloo, Waterloo, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis, Psoriatic / epidemiology*
Cardiovascular Diseases / epidemiology*
Cohort Studies
Comorbidity
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Ontario / epidemiology
Prevalence
Psoriasis / epidemiology*
Risk Assessment
Risk Factors
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Comments/Corrections
Comment In:
Orthopade. 2013 Feb;42(2):124

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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