Document Detail


Cardiovascular and noncardiovascular disease associations with hip fractures.
MedLine Citation:
PMID:  23331448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is growing awareness of an association between cardiovascular disease and fractures, and a temporal increase in fracture risk after myocardial infarction has been identified. To further explore the nature of this relationship, we systematically examined the association of hip fracture with all disease categories and assessed related secular trends.
METHODS: By using resources of the Rochester Epidemiology Project, a population-based incident case-control study was conducted. Disease history was compared among all Olmsted County, Minnesota, residents aged 50 years or more with a first radiographically confirmed hip fracture in 1985-2006 and community control subjects individually matched (1:1) to cases on age, sex, and index year (n = 3808; mean age, 82 years; standard deviation, 9 years; 76% were women).
RESULTS: All cardiovascular and numerous non-cardiovascular disease categories (eg, infectious diseases, nutritional and metabolic diseases, mental disorders, diseases of the nervous system and sense organs, and diseases of the respiratory system) were associated with fracture risk. However, increasing temporal trends were detected almost exclusively in cardiovascular disease categories. The largest increases in association were observed for ischemic heart disease, other forms of heart disease (including heart failure), hypertension, and diabetes, and were more pronounced among elderly women than other demographic subgroups.
CONCLUSIONS: Although the association with hip fracture was not specific to cardiovascular disease, temporal increases were mainly detected in cardiometabolic diseases, all of which have been linked previously to frailty. This mechanism and others warrant further investigation.
Authors:
Yariv Gerber; L Joseph Melton; Sheila M McNallan; Ruoxiang Jiang; Susan A Weston; Véronique L Roger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of medicine     Volume:  126     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169.e19-26     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cardiovascular Diseases / complications*
Case-Control Studies
Female
Hip Fractures / complications*
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Risk Factors
Grant Support
ID/Acronym/Agency:
P01 AG004875/AG/NIA NIH HHS; P01 AG04875/AG/NIA NIH HHS; R01 AG034676/AG/NIA NIH HHS; R01 AG034676/AG/NIA NIH HHS; R01 HL059205/HL/NHLBI NIH HHS; R01 HL072435/HL/NHLBI NIH HHS; R01 HL59205/HL/NHLBI NIH HHS; R01 HL72435/HL/NHLBI NIH HHS
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