Document Detail

Cardiovascular and neurohormonal effects of atrial natriuretic peptide in conscious dogs with and without chronic left ventricular dysfunction.
MedLine Citation:
PMID:  1697388     Owner:  NLM     Status:  MEDLINE    
Atrial natriuretic peptide (hANP 4-28) was infused for 1 h (0.3 microgram/kg/min) in 11 normal awake dogs and seven awake dogs with chronic left ventricular dysfunction, induced 16 weeks earlier by repetitive DC shock. The responses were similar in the two groups and included decreases in arterial pressure (107-99 mm Hg), heart rate (83-72 beats/min), and cardiac output (3.6-2.8 L/min), without changes in right or left ventricular filling pressures. Systemic vascular resistance (SVR) tended to rise during the infusion and was significantly increased (2,847-3,442 dyn s cm-5, p less than .05) during the postinfusion recovery period. Regional blood flows (microspheres) during infusion revealed a decrease in skin and splanchnic flow. Despite the apparent vasoconstrictor effect, plasma norepinephrine (PNE), renin activity (PRA), and arginine vasopressin (AVP) levels all fell during ANP infusion. These data suggest that ANP exerts a cardioinhibitory effect, possibly similar to that of arginine vasopressin (AVP), and that the net systemic vasoconstrictor effect of ANP in these dogs is mediated by a complex interrelationship between direct vascular effects, neurohormonal inhibition, and central reflex activation.
P Carson; P Carlyle; T S Rector; J N Cohn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  16     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-04     Completed Date:  1990-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455.
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MeSH Terms
Atrial Natriuretic Factor / blood,  pharmacology*
Cardiac Output / drug effects
Chronic Disease
Heart Diseases / blood,  physiopathology*
Heart Rate / drug effects
Heart Ventricles
Hemodynamics / drug effects*
Hormones / blood
Neurotransmitter Agents / blood*
Regional Blood Flow / drug effects
Renal Circulation / drug effects
Sodium / urine
Reg. No./Substance:
0/Hormones; 0/Neurotransmitter Agents; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor

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