| Cardiovascular modulation during vagus nerve stimulation therapy in patients with refractory epilepsy. | |
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MedLine Citation:
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PMID: 20863665 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To evaluate the effects of permanent vagal stimulation on cardiovascular system, 10 patients, affected by drug-resistant epilepsy with no primitive cardiovascular pathologies, were assessed prior to VNS surgery. A complete echocardiographic study [conventional and tissue Doppler imaging (TDI)], 24-h blood pressure (BP) monitoring and HRV evaluation were performed. The above mentioned parameters were investigated without any substantial changes to drug treatment during a check-up subsequent to VNS activation [mean: 7.7 months]. The results obtained show that while the anthropometrical data and both conventional and TDI echocardiography were unvaried compared to baseline, BP showed a significant increase of both systodiastolic values. Moreover, a close scrutiny of the most affected period of the BP increase (zenith between 16:31 and 17:30 pm) (systolic BP 114.7 mmHg vs 95.3 mmHg, P < 0.0001; diastolic BP 70.9 mmHg vs 56.9 mmHg, P < 0.001) showed a significant increase of the high frequencies components (HF) (28.4 ± 2.7 vs 36 ± 5.3, P < 0.05) and a significant reduction in low frequency/HF ratio (2.3 ± 0.3 vs 1.7 ± 0.3, P < 0.0001). The present study confirms the intrinsic cardiovascular safety and reliability of VNS procedures on both BP and HF and LF profiles and suggests that a primitive VNS-mediated central impingement on vagal efferents, independently by the antiepileptic mechanism, correlated to an moderate increase of parasympathetic activity, which in turn might play a protective role in seizure-triggered alterations of cardiovascular dynamic. |
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Authors:
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Christian Cadeddu; Martino Deidda; Giuseppe Mercuro; Antonella Tuveri; Antonella Muroni; Silvio Nocco; Monica Puligheddu; Alberto Maleci; Francesco Marrosu |
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Publication Detail:
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Type: Journal Article Date: 2010-09-21 |
Journal Detail:
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Title: Epilepsy research Volume: 92 ISSN: 1872-6844 ISO Abbreviation: Epilepsy Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Dept. of Cardiovascular and Neurological Sciences, University of Cagliari, Sardinia, Italy. cadedduc@unica.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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