| Cardiovascular and metabolic effects of CPAP in obese males with OSA. | |
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MedLine Citation:
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PMID: 17251237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obstructive sleep apnoea is associated with increased blood pressure and other features of the metabolic syndrome. The aim of the present study was to determine the relative effectiveness of continuous positive airway pressure (CPAP) in modifying these outcomes. A randomised placebo-controlled blinded crossover trial comparing cardiovascular and metabolic outcomes after 6 weeks of therapeutic and sham CPAP was performed in 34 CPAP-naïve patients (mean+/-SD body mass and respiratory disturbance indices were 36.1+/-7.6 and 39.7+/-13.8, respectively). Mean waking systolic and diastolic blood pressure fell by 6.7 and 4.9 mmHg, respectively, when compared with sham CPAP. No change was observed in glucose, lipids, insulin resistance or the proportion of patients with metabolic syndrome. In CPAP-compliant patients the fall in blood pressure was greater and the baroreceptor sensitivity improved significantly but no metabolic variable changed. In obese Caucasians with untreated obstructive sleep apnoea, continuous positive airways pressure can improve baroreceptor responsiveness and reduce waking blood pressure within 6 weeks, but this treatment period was insufficient to modify insulin resistance or change the metabolic profile. The mechanisms underlying this difference in the time course of blood pressure and metabolic response to continuous positive airway pressure in obstructive sleep apnoea requires further exploration. |
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Authors:
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S R Coughlin; L Mawdsley; J A Mugarza; J P H Wilding; P M A Calverley |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2007-01-24 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 29 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-02 Completed Date: 2007-06-27 Revised Date: 2008-06-27 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 720-7 Citation Subset: IM |
Affiliation:
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School of Clinical Sciences, Clinical Sciences Centre, University of Liverpool, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Composition Continuous Positive Airway Pressure* Cross-Over Studies Humans Insulin Resistance Male Metabolic Syndrome X / complications Middle Aged Obesity / complications* Placebos Sleep Apnea, Obstructive / complications* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Placebos |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2008 Jan;31(1):223-5
[PMID:
18166604
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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