Document Detail

Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure.
MedLine Citation:
PMID:  19488067     Owner:  NLM     Status:  MEDLINE    
Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.
D A Galvão; D R Taaffe; N Spry; D Joseph; R U Newton
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-02
Journal Detail:
Title:  Prostate cancer and prostatic diseases     Volume:  12     ISSN:  1476-5608     ISO Abbreviation:  Prostate Cancer Prostatic Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815755     Medline TA:  Prostate Cancer Prostatic Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-40     Citation Subset:  IM    
Vario Health Institute, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
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MeSH Terms
Androgen Antagonists / adverse effects*
Cardiovascular Diseases / etiology
Metabolic Diseases / etiology
Prostatic Neoplasms / drug therapy*
Risk Factors
Reg. No./Substance:
0/Androgen Antagonists

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