Document Detail

Cardiovascular manifestations of moderate to severe carbon monoxide poisoning.
MedLine Citation:
PMID:  15862427     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We describe the cardiovascular manifestations of carbon monoxide (CO) poisoning. BACKGROUND: Carbon monoxide poisoning is a common cause of toxicologic morbidity and mortality. Although the neurologic sequelae of CO poisoning have been well described, the cardiovascular consequences are limited to isolated case reports. METHODS: We reviewed the cardiovascular manifestations of 230 consecutive patients treated for moderate to severe CO poisoning in the hyperbaric oxygen chamber at Hennepin County Medical Center (HCMC), a regional center for treatment of CO poisoning. RESULTS: The mean age was 47.2 years with 72% men. Ischemic electrocardiogram (ECG) changes were present in 30% of patients, whereas only 16% had a normal ECG. Cardiac biomarkers (creatine kinase-MB fraction or troponin I) were elevated in 35% of patients. In-hospital mortality was 5%. CONCLUSIONS: Cardiovascular sequelae of CO poisoning are frequent, with myocardial injury assessed by biomarkers or ECG in 37% of patients. Patients admitted to the hospital with CO poisoning should have a baseline ECG and serial cardiac biomarkers.
Daniel Satran; Christopher R Henry; Cheryl Adkinson; Caren I Nicholson; Yiscah Bracha; Timothy D Henry
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  45     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-05-19     Revised Date:  2006-03-27    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1513-6     Citation Subset:  AIM; IM    
Division of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA.
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MeSH Terms
Aged, 80 and over
Carbon Monoxide Poisoning / blood,  epidemiology*,  etiology,  mortality,  physiopathology*
Cardiovascular System / physiopathology*
Creatine Kinase / blood
Creatine Kinase, MB Form
Isoenzymes / blood
Medical Records
Middle Aged
Minnesota / epidemiology
Retrospective Studies
Severity of Illness Index
Troponin I / blood
Reg. No./Substance:
0/Isoenzymes; 0/Troponin I; EC Kinase; EC Kinase, MB Form
Comment In:
J Am Coll Cardiol. 2006 Feb 7;47(3):690-1; author reply 691   [PMID:  16458163 ]

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