Document Detail

Cardiovascular manifestations of acute antibiotic toxicity during E coli endotoxin shock in anesthetized dogs.
MedLine Citation:
PMID:  394880     Owner:  NLM     Status:  MEDLINE    
Surgically instrumented, pentobarbital-anesthetized dogs were used to examine the acute cardiovascular activities of gentamicin, tobramycin, sodium penicillin-G, and sodium cephalothin during a control state and during experimental circulatory shock induced by E coli endotoxin. Intravenous administration of 2.5, 5, 10, and 20 mg/kg gentamicin or tobramycin resulted in a transient (5--20-minute) state of cardiovascular depression, as reflected by dose-related decreases of systemic blood pressure, cardiac output, left ventricular pressure, dP/dt max, left ventricular contractile force, and dF/dt max; heart rate was affected little. Endotoxin produced a persistent state of circulatory depression characterized by hypotension, decreased cardiac output, arterial acidemia, and reduced indices of cardiac function. During endotoxin shock, the cardiovascular effects of gentamicin and tobramycin were relatively more pronounced (sometimes more than doubled) than effects observed during the control state. Equally large doses of penicillin or cephalothin, however, had no discernible circulatory effects in either control dogs or dogs subjected to endotoxin shock. Present data indicate that the cardiovascular toxicities of the aminoglycoside antibiotics gentamicin and tobramycin were augmented during experimental circulatory shock, and suggest the need for specific hemodynamic surveillance when intravenous administration of cardioactive antibiotics is required in patients with pre-existing circulatory dysfunction.
H R Adams; J L Parker; B P Mathew
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  6     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1979  
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-404     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / toxicity*
Cephalothin / toxicity*
Depression, Chemical
Dose-Response Relationship, Drug
Escherichia coli*
Gentamicins / toxicity*
Hemodynamics / drug effects*
Penicillin G / toxicity*
Shock, Septic / physiopathology*
Tobramycin / toxicity*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 153-61-7/Cephalothin; 32986-56-4/Tobramycin; 61-33-6/Penicillin G; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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