Document Detail

Cardiovascular management of pregnant women with a heart valve prosthesis.
MedLine Citation:
PMID:  1199937     Owner:  NLM     Status:  MEDLINE    
This study of 14 pregnancies in 11 patients with a Starr-Edwards valve prosthesis (nine mitral, two aortic) shows that cardiac functional capacity deteriorated to class III (New York Heart Association criteria) in only 1 woman. The deterioration occurred during the third trimester and the patient's condition improved with medical therapy. Careful medical control diminished the incidence of heart failure in these patients. Six of nine pregnant women with a mitral valve prosthesis were treated continuously with coumarin and three discontinued the therapy gradually before the third trimester of pregnancy. In five pregnant women (three with an aortic valve prosthesis, two with a mitral valve prosthesis) no anticoagulant agents were used. No embolic episodes or severe hemorrhagic complications were seen. One newborn whose mother received coumarin during the first trimester had bilateral hand polydactylia. There were no maternal deaths. One neonate died after fetal stress necessitating the only cesarean section. These results suggest that women with an artificial heart valve tolerate pregnancy well and that anticoagulant therapy is not mandatory in pregnant women with an aortic valve prosthesis, or in the few women with a mitral valve prosthesis not already receiving coumarin at the onset of pregnancy.
P Casanegra; G Avilés; G Maturana; J Dubernet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  36     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  802-6     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve / surgery
Coumarins / therapeutic use
Heart Failure / prevention & control
Heart Valve Prosthesis*
Infant, Newborn
Maternal Mortality
Mitral Valve / surgery
Pregnancy Complications, Cardiovascular / drug therapy,  therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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