|Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease.|
|PMID: 22936681 Owner: NLM Status: MEDLINE|
|OBJECTIVE: To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology.
DESIGN: Prospective study.
SETTING: Tertiary referral cardiology centre in London, UK.
PATIENTS: 192 patients were mainly recruited from specialist clinics. We studied patients with Anderson-Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects.
RESULTS: In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns.
CONCLUSIONS: Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease.
|Daniel M Sado; Andrew S Flett; Sanjay M Banypersad; Steven K White; Viviana Maestrini; Giovanni Quarta; Robin H Lachmann; Elaine Murphy; Atul Mehta; Derralynn A Hughes; William J McKenna; Andrew M Taylor; Derek J Hausenloy; Philip N Hawkins; Perry M Elliott; James C Moon|
|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-08-30|
|Title: Heart (British Cardiac Society) Volume: 98 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2012 Oct|
|Created Date: 2012-09-11 Completed Date: 2012-11-13 Revised Date: 2014-02-20|
Medline Journal Info:
|Nlm Unique ID: 9602087 Medline TA: Heart Country: England|
|Languages: eng Pagination: 1436-41 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Analysis of Variance
Contrast Media / diagnostic use*
Heart Atria / pathology
Heart Diseases / diagnosis*, pathology, physiopathology
Heart Septum / pathology
Heart Ventricles / pathology, physiopathology
Magnetic Resonance Imaging*
Meglumine / diagnostic use*
Myocardium / pathology*
Organometallic Compounds / diagnostic use*
Predictive Value of Tests
Ventricular Function, Left
|FS/10/72/28568//British Heart Foundation; //British Heart Foundation|
|0/Contrast Media; 0/Organometallic Compounds; 0/gadoterate meglumine; 6HG8UB2MUY/Meglumine|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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