| Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease. | |
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MedLine Citation:
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PMID: 22936681 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology. DESIGN: Prospective study. SETTING: Tertiary referral cardiology centre in London, UK. PATIENTS: 192 patients were mainly recruited from specialist clinics. We studied patients with Anderson-Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects. RESULTS: In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns. CONCLUSIONS: Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease. |
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Authors:
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Daniel M Sado; Andrew S Flett; Sanjay M Banypersad; Steven K White; Viviana Maestrini; Giovanni Quarta; Robin H Lachmann; Elaine Murphy; Atul Mehta; Derralynn A Hughes; William J McKenna; Andrew M Taylor; Derek J Hausenloy; Philip N Hawkins; Perry M Elliott; James C Moon |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-30 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: - ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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