Document Detail

Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease.
MedLine Citation:
PMID:  22936681     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology.
DESIGN: Prospective study.
SETTING: Tertiary referral cardiology centre in London, UK.
PATIENTS: 192 patients were mainly recruited from specialist clinics. We studied patients with Anderson-Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects.
RESULTS: In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns.
CONCLUSIONS: Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease.
Daniel M Sado; Andrew S Flett; Sanjay M Banypersad; Steven K White; Viviana Maestrini; Giovanni Quarta; Robin H Lachmann; Elaine Murphy; Atul Mehta; Derralynn A Hughes; William J McKenna; Andrew M Taylor; Derek J Hausenloy; Philip N Hawkins; Perry M Elliott; James C Moon
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-30
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  98     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-11     Completed Date:  2012-11-13     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1436-41     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Contrast Media / diagnostic use*
Heart Atria / pathology
Heart Diseases / diagnosis*,  pathology,  physiopathology
Heart Septum / pathology
Heart Ventricles / pathology,  physiopathology
Magnetic Resonance Imaging*
Meglumine / diagnostic use*
Middle Aged
Myocardium / pathology*
Organometallic Compounds / diagnostic use*
Predictive Value of Tests
Prospective Studies
Reference Values
Sex Factors
Stroke Volume
Ventricular Function, Left
Young Adult
Grant Support
FS/10/72/28568//British Heart Foundation; //British Heart Foundation
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 0/gadoterate meglumine; 6HG8UB2MUY/Meglumine

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