Document Detail


Cardiovascular magnetic resonance imaging detects cardiac involvement in Churg-Strauss syndrome.
MedLine Citation:
PMID:  19041050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cardiac involvement in Churg-Strauss vasculitis worsens the prognosis. Early detection is, therefore, warranted. Cardiac magnetic resonance (CMR) can visualize various forms of inflammatory changes in the myocardium. We tested whether CMR could elucidate cardiac damage in patients with biopsy-proven Churg-Strauss syndrome and clinical evidence of cardiac involvement. METHODS AND RESULTS: Eleven patients underwent a CMR protocol including cine imaging for left ventricular function in long axes, T2-weighted imaging for edema detection, and contrast-enhanced T1-weighting for early and late gadolinium enhancement. CMR detected various form of myocardial injury in all patients. Systolic left ventricular function was impaired in 6 patients. Mean left ventricular ejection fraction was 45 +/- 15%. Left ventricular size was mildly enlarged (left ventricular end-diastolic volume index 94 +/- 23 mL/m(2)). Edema was present in 4 cases; 7 patients had pericardial effusion. Six patients had increased early contrast uptake. CMR detected late enhancement lesions in 9 of 11 patients, even in those with normal left ventricular size and function. CONCLUSIONS: CMR has the potential to detect myocardial injury in Churg-Strauss syndrome even when left ventricular function appears normal.
Authors:
Ralf Wassmuth; Ursula Göbel; Alexander Natusch; Wolfgang Schneider; Ralph Kettritz; Rainer Dietz; Friedrich C Luft; Jeanette Schulz-Menger
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-08-22
Journal Detail:
Title:  Journal of cardiac failure     Volume:  14     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  856-60     Citation Subset:  IM    
Affiliation:
Cardiology Department, Franz-Volhard-Klinik, Charite Campus Buch, and HELIOS-Klinikum Berlin, Berlin, Germany. ralf.wassmuth@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cardiovascular System / pathology
Churg-Strauss Syndrome / diagnosis,  pathology*
Echo-Planar Imaging / methods*
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Myocardium / pathology*
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