Document Detail

Cardiovascular ion channels as a molecular target of flavonoids.
MedLine Citation:
PMID:  20633021     Owner:  NLM     Status:  MEDLINE    
Flavonoids are a class of naturally occurring polyphenols abundant in edibles and beverages of plant origin. Epidemiological studies consistently associate high flavonoid intake with a reduced risk for the development of cardiovascular diseases. So far these beneficial effects have been mainly attributed to nonspecific antioxidant and antiinflammatory properties. However, there is an increasing body of evidence that flavonoids specifically target molecular structures including cardiovascular ion channels. Playing a pivotal role in the regulation of vascular tone and cardiac electric activity, ion channels represent a major target for the induction of antihypertensive and cardioprotective effects. Thus, pharmacological properties of flavonoids on cardiovascular ion channels, ion currents and tissue preparations are being increasingly addressed in experimental studies. Whereas it has become clear that cardiovascular ion channels represent an important molecular target of flavonoids, the published data have not yet been systematically reviewed.
Eberhard P Scholz; Edgar Zitron; Hugo A Katus; Christoph A Karle
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  28     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  e46-52     Citation Subset:  IM    
Department of Internal Medicine III (Cardiology), University Hospital Heidelberg, Heidelberg, Germany.
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MeSH Terms
Cardiovascular Agents / pharmacology*
Cardiovascular Diseases / metabolism,  physiopathology,  prevention & control*
Cardiovascular System / drug effects*,  metabolism,  physiopathology
Dietary Supplements*
Flavonoids / pharmacology*
Ion Channels / drug effects*,  metabolism
Ion Transport
Membrane Potentials
Reg. No./Substance:
0/Cardiovascular Agents; 0/Flavonoids; 0/Ion Channels

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