| Cardiovascular ion channels as a molecular target of flavonoids. | |
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MedLine Citation:
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PMID: 20633021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Flavonoids are a class of naturally occurring polyphenols abundant in edibles and beverages of plant origin. Epidemiological studies consistently associate high flavonoid intake with a reduced risk for the development of cardiovascular diseases. So far these beneficial effects have been mainly attributed to nonspecific antioxidant and antiinflammatory properties. However, there is an increasing body of evidence that flavonoids specifically target molecular structures including cardiovascular ion channels. Playing a pivotal role in the regulation of vascular tone and cardiac electric activity, ion channels represent a major target for the induction of antihypertensive and cardioprotective effects. Thus, pharmacological properties of flavonoids on cardiovascular ion channels, ion currents and tissue preparations are being increasingly addressed in experimental studies. Whereas it has become clear that cardiovascular ion channels represent an important molecular target of flavonoids, the published data have not yet been systematically reviewed. |
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Authors:
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Eberhard P Scholz; Edgar Zitron; Hugo A Katus; Christoph A Karle |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular therapeutics Volume: 28 ISSN: 1755-5922 ISO Abbreviation: Cardiovasc Ther Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101319630 Medline TA: Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: e46-52 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine III (Cardiology), University Hospital Heidelberg, Heidelberg, Germany. eberhard.scholz@med.uni-heidelberg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Agents / pharmacology* Cardiovascular Diseases / metabolism, physiopathology, prevention & control* Cardiovascular System / drug effects*, metabolism, physiopathology Dietary Supplements* Flavonoids / pharmacology* Humans Ion Channels / drug effects*, metabolism Ion Transport Membrane Potentials |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Flavonoids; 0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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