Document Detail

Cardiovascular instability induced by intracerebroventricular administration of vasopressin or corticotrophin-releasing factor in conscious long evans and brattleboro rats.
MedLine Citation:
PMID:  19210395     Owner:  NLM     Status:  In-Data-Review    
Abstract Conscious Long Evans and Brattleboro rats, chronically instrumented with pulsed Doppler probes around left renal and superior mesenteric arteries and the distal abdominal aorta, had vasopressin or corticotrophin-releasing factor administered intracerebroventricularly. In Long Evans rats, vasopressin caused no cardiovascular instability, but in Brattleboro rats, vasopressin caused the development of marked oscillations in blood pressure and heart rate. Under the latter conditions, falls in blood pressure were accompanied by increases in hindquarter blood flow. Similar oscillations in blood pressure, heart rate and regional haemodynamics were seen in Long Evans and Brattleboro rats given corticotrophin-releasing factor. These results indicate that centrally-administered vasopressin and corticotrophin-releasing factor can have an important influence on the control of regional haemodynamics. In some respects the effects of the peptides resemble the changes seen during the defence reaction.
S M Gardiner; A M Compton; T Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  2     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  2009-02-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  -    
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.
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