| Cardiovascular hypertrophy in one-kidney, one-clip renal hypertension is resistant to heparin. | |
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MedLine Citation:
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PMID: 15126919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Heparin inhibits vascular hypertrophy in angiotensin-induced hypertension, in addition to its well-known role in inhibiting injury-induced vascular smooth muscle proliferation. We tested whether hypertension and vascular hypertrophy could be reduced by heparin independently from the renin-angiotensin system. METHODS: Rats were made hypertensive with a one-kidney, one-clip (1K1C) procedure and received heparin from osmotic minipumps (0.3 mg/h per kg i.v.) or saline vehicle for 2 weeks. Blood pressure was measured by the tail-cuff method and vessel cross-sectional area was measured by morphometry in the aorta and mesenteric arteries. Proliferation was assessed with bromodeoxyuridine labelling. RESULTS: Blood pressure elevation and cardiovascular hypertrophy were evident in 1K1C rats. The media of mesenteric arteries was increased by 25%, and the media : lumen ratio by 35%, in hypertensive rats. DNA synthesis by smooth muscle cells in the mesenteric arteries was increased sevenfold in renal hypertension. Heparin treatment did not influence either the increase in blood pressure, the cardiovascular hypertrophy response or hypertension-mediated proliferation of arterial smooth muscle cells. CONCLUSIONS: These data suggest that the vascular hypertrophy mechanisms operating in 1K1C renal hypertension are not inhibited by heparin and thus are different from those in angiotensin-mediated hypertension. Identifying such mechanisms in the future will be important for devising appropriate intervention strategies in angiotensin-independent forms of vascular hypertrophy. |
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Authors:
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Rodney J Dilley; Bishoy Rizkalla; John F Bertram |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 22 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-05-05 Completed Date: 2004-12-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 767-74 Citation Subset: IM |
Affiliation:
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Morphology Laboratory, Baker Heart Research Institute, Prahran, Australia. rod.dilley@baker.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology Animals Aorta, Thoracic / cytology, metabolism Blood Pressure Body Weight / drug effects Cell Division DNA / biosynthesis Heparin / therapeutic use* Hypertension, Renal / metabolism* Hypertrophy Male Mesenteric Arteries / cytology, metabolism Muscle, Smooth, Vascular / metabolism Organ Size / drug effects Rats Rats, Inbred WKY Time Factors |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 9005-49-6/Heparin; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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