Document Detail

Cardiovascular hypertrophy does not predispose to genetic hypertension.
MedLine Citation:
PMID:  9247736     Owner:  NLM     Status:  MEDLINE    
It has been proposed that cardiovascular hypertrophy precedes and contributes to the development of genetic hypertension. In a genetically segregating population we determined whether susceptibility to high blood pressure was associated with cardiovascular structural abnormalities in youth. In 9-week old male F2 rats derived from a cross of spontaneously hypertensive rats (SHR) and inbred normotensive Donryu (DRY) rats we determined left ventricular mass (LVM) by echocardiography and the media-lumen ratio (MLR) of mesenteric resistance vessels by biopsy. Direct mean arterial pressure was measured in the same rats at 20 weeks of age. The ranges of LVM and MLR in young F2 rats encompassed values seen SHR and DRY at this age. However, no correlation was observed between LVM or MLR and subsequent blood pressures at 20 weeks of age. The blood pressure of F2 rats with cardiovascular structural phenotypes within the SHR range was no higher than the remainder of the F2 population. These studies do not support the hypothesis that hypertrophy of the heart or mesenteric resistance vessels confer susceptibility to the development of genetic hypertension.
S B Harrap; E F Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  19     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-09-29     Completed Date:  1997-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-41     Citation Subset:  IM    
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Cardiomegaly / complications*,  genetics,  pathology
Crosses, Genetic
Disease Models, Animal
Heart Ventricles / pathology
Hypertension / etiology*,  genetics*,  pathology
Mesenteric Arteries / pathology
Rats, Inbred SHR

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