| Cardiovascular and hormonal responses to cold pressor test in insulin-dependent diabetic adolescents with microalbuminuria. | |
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MedLine Citation:
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PMID: 8061351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular responses to cold pressor test and associated changes in blood concentrations of renin, aldosterone, and catecholamines were measured in 11 type I diabetic patients with microalbuminuria; 11 type I diabetic patients with normoalbuminuria matched for age, duration of diabetes, metabolic control; and in nine normal control subjects. Heart rate, renin, aldosterone, and catecholamines concentrations in diabetic patients and controls at baseline were similar, but higher mean blood pressure was evident in microalbuminuric than normoalbuminuric patients (p < 0.01) and controls (p < 0.05). Heart rate and mean blood pressure during cold pressor test in control subjects and type I diabetic patients increased significantly but similarly, regardless of the presence of microalbuminuria. Catecholamines, but not renin-aldosterone release, was associated to blood pressure modifications during the test. Peak values of mean blood pressure induced by cold test were positively correlated to baseline values in control subjects (r = 0.658, p < 0.05) and normoalbuminuric (r = 0.725, p < 0.01), but not microalbuminuric diabetics. These data suggest that the higher blood-pressure values at rest observed in microalbuminuric than normoalbuminuric diabetics are not associated with a higher cardiovascular response to cold hypertensive stimulus. |
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Authors:
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E Bognetti; F Meschi; M Rota; D Cofano; A Palermo; G Chiumello |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of diabetes and its complications Volume: 8 ISSN: 1056-8727 ISO Abbreviation: J. Diabetes Complicat. Publication Date: 1994 Apr-Jun |
Date Detail:
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Created Date: 1994-09-22 Completed Date: 1994-09-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9204583 Medline TA: J Diabetes Complications Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 84-8 Citation Subset: IM |
Affiliation:
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Scientific Institute H San Raffaele, Department of Pediatrics, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Albuminuria / etiology, physiopathology* Blood Pressure / physiology* Catecholamines / physiology* Cold Temperature Diabetes Mellitus, Type 1 / physiopathology*, urine Diabetic Nephropathies / physiopathology*, urine Female Heart Rate / physiology Humans Male Renin-Angiotensin System / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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