| Cardiovascular function in women with recurrent miscarriage, preeclampsia and/or intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 23039814 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: To investigate pre-pregnancy cardiovascular function and risk factors in women with previous pregnancy complications. Methods: Thirty-four women with previous normal pregnancy (controls), 26 with unexplained recurrent miscarriage (RM) and 14 with preeclampsia (PE) and/or intrauterine growth restriction (IUGR), planning to conceive were recruited. Brachial and central blood pressures (BP), cardiac output (CO), peripheral vascular resistance (PVR), aortic stiffness, blood biochemistry and platelet aggregation were assessed. Results: Women with previous PE/IUGR had higher brachial diastolic BP (78±9 vs 71±7mmHg; P=0.03), central systolic BP (107±10 vs 99±8mmHg; P=0.03), mean arterial pressure (92±10 vs 84±8mmHg; P=0.01) and PVR (1499±300 vs 1250±220dynes.s-1cm-5; P =0.005), than the controls. No differences were observed in either cardiovascular function or blood biochemistry in women with unexplained RM compared to the controls. Women with previous PE/IUGR though not with RM had a stronger family history of cardiovascular disease (CVD) than controls. Conclusions: Women with previous PE and/or IUGR had higher BP and PVR compared to controls, which may predispose them to CVD later in life. However, in the absence of underlying vascular pathology, women with unexplained RM did not have abnormal cardiovascular function. Pre-pregnancy period provides an opportunity to identify cardiovascular risks in relation to previous obstetric history. |
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Authors:
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Amita A Mahendru; Thomas R Everett; M McEniery; Ian B Wilkinson; Christoph C Lees |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Fetal Medicine Department, Rosie Hospital, Addenbrooke's Hospital, Cambridge University Hospitals Foundation Trust, Hills Road, Cambridge, CB2 2QQ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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