Document Detail


Cardiovascular function in normotensive offspring of persons with essential hypertension and black race.
MedLine Citation:
PMID:  17617759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior investigations have shown impaired endothelial function in hypertensive blacks when compared with whites. It is not clear, however, whether the difference in vascular responsiveness predates or follows the development of hypertension. Thirty-nine young black adults with a family history of essential hypertension and 41 control participants were studied for brachial artery reactivity and carotid intima-media thickness via ultrasonography, cardiac muscle mass and diastolic function by echocardiography, and biochemical analysis. There was no significant difference in brachial artery reactivity between the study groups, although women had greater reactivity than men (P=.05). Carotid intima-media thickness, left ventricular geometry, and biomarkers were equivalent between the study groups (P=not significant). Vascular imaging and biomarkers were unable to identify early evidence of endothelial dysfunction in offspring of African Americans with essential hypertension. These same studies demonstrated some early changes in vascular function based on sex.
Authors:
Emile R Mohler; Kitty O'Hare; Eduardo S Darze; Raymond R Townsend; Charles R Bridges; Martin G Keane
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  9     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  506-12     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. mohlere@uphs.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group / genetics*
Biological Markers / blood
Brachial Artery / physiopathology
Carotid Stenosis / genetics*,  physiopathology
Diastole / physiology
Echocardiography*
Echocardiography, Doppler, Color
Endothelium, Vascular / physiopathology
Female
Genetic Predisposition to Disease / genetics
Humans
Hypertension / genetics*,  physiopathology
Hypertrophy, Left Ventricular / genetics*,  physiopathology
Male
Nitroglycerin / diagnostic use
Reference Values
Sex Factors
Ultrasonography
Vasodilation / physiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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