Document Detail

Cardiovascular function in a chronic peritoneal dialysis pediatric population on recombinant human erythropoietin treatment.
MedLine Citation:
PMID:  8399585     Owner:  NLM     Status:  MEDLINE    
Anemia, through a hyperkinetic state, is an important contributor to myocardial function impairment. To determine the cardiovascular effects of recombinant human erythropoietin (rHuEPO) therapy, 10 chronic peritoneal dialysis (CPD)-treated anemic children were studied before and during 18 months of treatment. The following parameters were recorded: hemoglobin (Hb) [percent of target level (TL) = x-2 standard deviations of normal Hb values for age and sex], heart rate (HR, beats/minute), mean arterial pressure (MAP, mmHg), end-diastolic left ventricular diameter (EDLVD, mm/sm BSA), shortening fraction (SF, percent), and interventricular septal thickness (IVS, mm/sm BSA). Student's t-test for paired data showed (vs time before treatment, T0) a progressive increase in Hb, a progressive decrease in HR, and a progressive increase in MAP. EDLVD progressively decreased, while SF and IVS remained unchanged throughout the study. Regression analysis showed a close correlation between anemia correction and decrease of HR (p < 0.01), while no correlation was found between Hb and EDLVD or SF, IVS, or MAP. Our data indicate that anemia correction in these patients is mainly associated with a decrease in hyperkinetic state (HR reduction with SF unvaried), while left ventricular function and dimensions remain normal, despite an increase in MAP.
S Bassi; G Montini; A Edefonti; F Perfumo; D Cattarelli; G Piaggio; V Fesslova; G Zacchello; S Bove
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  13 Suppl 2     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-01     Completed Date:  1993-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  S267-9     Citation Subset:  IM    
Department of Nephrology, Children's Hospital, Brescia, Italy.
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MeSH Terms
Anemia / blood,  etiology,  physiopathology,  therapy
Blood Pressure
Erythropoietin / therapeutic use*
Heart / physiopathology*
Heart Rate
Hemoglobins / analysis
Kidney Failure, Chronic / complications
Myocardial Contraction
Peritoneal Dialysis*
Prospective Studies
Recombinant Proteins / therapeutic use
Ventricular Function, Left
Reg. No./Substance:
0/Hemoglobins; 0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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