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Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow.
MedLine Citation:
PMID:  23023990     Owner:  NLM     Status:  Publisher    
Objectives Intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (22-25 years) who were born at term after IUGR and 18 controls, all previously examined with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tonometry, blood pressure and laser Doppler in order to characterize their cardiac and vascular geometry and/or function. Results The diameter of the ascending aorta and the left ventricular diameter was smaller in the IUGR group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (p<0.05). The aortic pressure augmentation index was higher in the IUGR group (p<0.05). The common carotid artery diameter, intima-media thickness and distensibilty as well as left ventricular mass and function were similar in the two groups. IUGR status was found to be an independent predictor of the ascending aortic diameter. Conclusions Fetal growth restriction due to placental dysfunction seems to contribute to the higher systolic blood pressure augmentation and the smaller aortic dimension that are observed more than twenty years later. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Niclas Bjarnegård; Eva Morsing; Magnus Cinthio; Toste Länne; Jana Brodszki
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Medical and Health Sciences, Linköping University, 581 85 Linköping, Sweden.
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