| Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii. | |
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MedLine Citation:
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PMID: 16886775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The crustacean nervous system is an important source of substances with diverse biological activities, particularly affecting invertebrate cardiocirculatory physiology. However, the effects of these substances on the cardiovascular system of higher vertebrates are not very well documented. The purpose of this study was to evaluate the effects of a cardioexcitatory substance (CES) isolated from the eyestalk of the shrimp Peneaus vanameii on rat cardiovascular function. The administration of a purified fraction of this substance raised mean arterial pressure by 37.33 +/- 5.00 mm Hg, pulse pressure 35.00 +/- 4.93 mm Hg and heart rate 80.00 +/- 12.83 beats/min over basal values (p < 0.01). Evaluation of the possible underlying mechanisms of this hypertensive and tachycardic effect reveled that dihydroergotamine pretreatment (20 microg/0.2 mL) reduced the effect of CES on mean blood pressure, but not on heart rate. Propranolol pretreatment (4 microg/0.2 mL) reduced the tachycardia, but not the hypertensive response. Enalapril pretreatment (5 microg/0.2 mL) did not modify the effects induced by CES on heart rate or blood pressure, and the verapamil pretreatment (1 microg/0.2 mL) reduced both cardiovascular changes by 85% (p < 0.01). These results indicate that CES isolated from the shrimp eyestalk produces hypertension and tachycardia mediated by adrenergic receptors in association to calcium channels activation. |
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Authors:
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Francisco Rosa; Jesús Cedeño; Luis León; Omar Estrada; Eduardo Romero-Vecchione; José Vásquez; Rafael Antequera |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigación clínica Volume: 47 ISSN: 0535-5133 ISO Abbreviation: Invest Clin Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-08-04 Completed Date: 2006-09-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421531 Medline TA: Invest Clin Country: Venezuela |
Other Details:
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Languages: eng Pagination: 133-41 Citation Subset: IM |
Affiliation:
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Departamento de Ciencias Fisiológicas, Escuela de Ciencias de la Salud, Núcleo Bolívar, Universidad Central de Venezuela, Caracas. frankrosa@cantv.net |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Structures
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chemistry Animals Anti-Arrhythmia Agents / pharmacology, therapeutic use Antihypertensive Agents / pharmacology, therapeutic use Blood Pressure / drug effects Calcium Channels / drug effects Cardiotonic Agents / isolation & purification, pharmacology* Dihydroergotamine / pharmacology, therapeutic use Drug Evaluation, Preclinical Enalapril / pharmacology, therapeutic use Ganglia, Invertebrate / drug effects Heart Rate / drug effects Hemodynamics / drug effects* Hypertension / chemically induced, prevention & control Male Motor Neurons / drug effects Neuropeptides / isolation & purification, pharmacology* Penaeidae / chemistry* Premedication Propranolol / pharmacology, therapeutic use Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta / drug effects Tachycardia / chemically induced, prevention & control Tissue Extracts / isolation & purification, pharmacology* Verapamil / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Calcium Channels; 0/Cardiotonic Agents; 0/Neuropeptides; 0/Receptors, Adrenergic, beta; 0/Tissue Extracts; 511-12-6/Dihydroergotamine; 52-53-9/Verapamil; 525-66-6/Propranolol; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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