Document Detail

Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameii.
MedLine Citation:
PMID:  16886775     Owner:  NLM     Status:  MEDLINE    
The crustacean nervous system is an important source of substances with diverse biological activities, particularly affecting invertebrate cardiocirculatory physiology. However, the effects of these substances on the cardiovascular system of higher vertebrates are not very well documented. The purpose of this study was to evaluate the effects of a cardioexcitatory substance (CES) isolated from the eyestalk of the shrimp Peneaus vanameii on rat cardiovascular function. The administration of a purified fraction of this substance raised mean arterial pressure by 37.33 +/- 5.00 mm Hg, pulse pressure 35.00 +/- 4.93 mm Hg and heart rate 80.00 +/- 12.83 beats/min over basal values (p < 0.01). Evaluation of the possible underlying mechanisms of this hypertensive and tachycardic effect reveled that dihydroergotamine pretreatment (20 microg/0.2 mL) reduced the effect of CES on mean blood pressure, but not on heart rate. Propranolol pretreatment (4 microg/0.2 mL) reduced the tachycardia, but not the hypertensive response. Enalapril pretreatment (5 microg/0.2 mL) did not modify the effects induced by CES on heart rate or blood pressure, and the verapamil pretreatment (1 microg/0.2 mL) reduced both cardiovascular changes by 85% (p < 0.01). These results indicate that CES isolated from the shrimp eyestalk produces hypertension and tachycardia mediated by adrenergic receptors in association to calcium channels activation.
Francisco Rosa; Jesús Cedeño; Luis León; Omar Estrada; Eduardo Romero-Vecchione; José Vásquez; Rafael Antequera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigación clínica     Volume:  47     ISSN:  0535-5133     ISO Abbreviation:  Invest Clin     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-08-04     Completed Date:  2006-09-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421531     Medline TA:  Invest Clin     Country:  Venezuela    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Departamento de Ciencias Fisiológicas, Escuela de Ciencias de la Salud, Núcleo Bolívar, Universidad Central de Venezuela, Caracas.
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MeSH Terms
Animal Structures / chemistry
Anti-Arrhythmia Agents / pharmacology,  therapeutic use
Antihypertensive Agents / pharmacology,  therapeutic use
Blood Pressure / drug effects
Calcium Channels / drug effects
Cardiotonic Agents / isolation & purification,  pharmacology*
Dihydroergotamine / pharmacology,  therapeutic use
Drug Evaluation, Preclinical
Enalapril / pharmacology,  therapeutic use
Ganglia, Invertebrate / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / chemically induced,  prevention & control
Motor Neurons / drug effects
Neuropeptides / isolation & purification,  pharmacology*
Penaeidae / chemistry*
Propranolol / pharmacology,  therapeutic use
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / drug effects
Tachycardia / chemically induced,  prevention & control
Tissue Extracts / isolation & purification,  pharmacology*
Verapamil / pharmacology,  therapeutic use
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Calcium Channels; 0/Cardiotonic Agents; 0/Neuropeptides; 0/Receptors, Adrenergic, beta; 0/Tissue Extracts; 511-12-6/Dihydroergotamine; 52-53-9/Verapamil; 525-66-6/Propranolol; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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