Document Detail

Cardiovascular effects of hypoxia/hypercarbia and tension pneumothorax in newborn piglets.
MedLine Citation:
PMID:  8062569     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To test the hypothesis that, in newborn piglets, the presence of a tension pneumothorax modifies the cardiovascular responses to hypoxia/hypercarbia. DESIGN: Prospective laboratory study. SETTING: Perinatal cardiovascular research laboratory at a university school of medicine. SUBJECTS: Seven newborn piglets. INTERVENTIONS: We sequentially exposed the piglets to a baseline (control I) measure, hypoxia/hypercarbia, tension pneumothorax with normoxia/normocarbia, and tension pneumothorax with hypoxia/hypercarbia added. MEASUREMENTS AND MAIN RESULTS: Brain and systemic blood pressures and blood flow (radionuclide-microspheres) were measured. Hypoxia/hypercarbia resulted in increased brain perfusion (207 +/- 61% of control, mean +/- SEM, p < .05) and heart perfusion (176 +/- 58% of control, p < .05) and decreased gastrointestinal perfusion (-37 +/- 9% of control, p < .05). Tension pneumothorax with normoxia/normocarbia reduced the cardiac output (-70 +/- 8% of control, p < .05), which was redistributed toward the brain (p < .05) at the expense of the gastrointestinal tract (p < .05). Although this redistribution in cardiac output persisted during tension pneumothorax with hypoxia/hypercarbia added, sustained reductions in cardiac output (-57 +/- 11%, of control, p < .01) were associated with smaller increases in perfusion to brain (55 +/- 54 vs. 207 +/- 61% of control, tension pneumothorax with hypoxia/hypercarbia added, and hypoxia/hypercarbia time periods, respectively, p < .05) and heart (65 +/- 49 vs. 176 +/- 58% of control, tension pneumothorax with hypoxia/hypercarbia added, and hypoxia/hypercarbia time periods, respectively, p < .05) and larger decreases in blood flow to gastrointestinal tract, pancreas, and kidneys (p < .05) than with hypoxia/hypercarbia alone. CONCLUSIONS: Tension pneumothorax-induced reductions in cardiac output limit the hypoxia/hypercarbia-mediated increases in perfusion to brain and heart and accentuate the hypoxia/hypercarbia-related decreases in perfusion to kidneys and splanchnic organs.
B S Brann; S R Mayfield; M Goldstein; W Oh; B S Stonestreet
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  22     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-22     Completed Date:  1994-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1453-60     Citation Subset:  AIM; IM    
Department of Pediatrics, Brown University School of Medicine, Women and Infant's Hospital of Rhode Island, Providence 02905.
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MeSH Terms
Analysis of Variance
Animals, Newborn / physiology*
Anoxia / physiopathology*
Cardiovascular System / physiopathology*
Hemodynamics / physiology
Hypercapnia / physiopathology*
Pneumothorax / physiopathology*
Grant Support
Comment In:
Crit Care Med. 1995 Aug;23(8):1446-8   [PMID:  7634820 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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