Document Detail


Cardiovascular effects of surfactant suspensions given by tracheal instillation to premature lambs.
MedLine Citation:
PMID:  6553821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After delivery by cesarean section at 133-136 days gestational age, 18 lambs were supported with infant ventilators. Peak inspiratory pressure was the only ventilator setting that was changed in an attempt to normalize PCO2. The lambs were retrospectively divided into two groups based on their respiratory status before treatment. Ten lambs with PCO2 values of 38 +/- 2 mmHg (mean +/- S.E.) at 5 h of age were treated with a 15-ml suspension containing 50 mg natural sheep surfactant lipid/kg body weight. After surfactant instillation, pH fell, PCO2 increased and compliance/kg decreased transiently. Surfactant treatment did not reduce the respiratory support that these lambs required. Eight lambs with PCO2 values of 68 +/- 3 mmHg at 3 +/- 0.8 h of age responded to surfactant instillation with a decrease in PCO2 and an increase in PO2 and pH. In both groups of lambs heart rates, mean aortic pressures, and mean pulmonary artery pressures changed little after surfactant instillation. Cardiac outputs and regional blood flows measured before and after surfactant treatment were unchanged. Instillation of surfactant suspensions to premature lambs did not adversely affect cardiovascular status; however, some lambs did have a transient deterioration of lung function after surfactant instillation.
Authors:
A Jobe; H Jacobs; M Ikegami; S Jones
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  17     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  444-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Output / drug effects*
Coronary Circulation / drug effects
Heart Rate / drug effects*
Humans
Infant, Newborn
Pulmonary Surfactants / administration & dosage*,  therapeutic use
Respiratory Distress Syndrome, Newborn / drug therapy*
Sheep
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS; HD-HL-00252/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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