Document Detail


Cardiovascular effects and safety of intravenous and intramuscular pentamidine isethionate.
MedLine Citation:
PMID:  3494569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intramuscular (im) pentamidine isethionate can cause substantial local pain and inflammation at the injection site. This drug is being used more frequently in recent years to treat Pneumocystis pneumonia, particularly in patients with acquired immunodeficiency syndrome. Clinicians began administering it iv despite warnings that iv administration might cause severe hypotension. We investigated the safety of im and iv pentamidine, monitoring hemodynamics after each dose in 11 patients with intra-arterial lines. Results showed only a small (but statistically significant) fall in mean arterial pressure after both im and slow (60 min) iv administration. A concomitant decrease in pulse occurred, but no change in cardiac output, pulmonary capillary occlusion pressure or systemic vascular resistance was noted. These results suggest that it may be safe to infuse pentamidine slowly intravenously. This route is more comfortable to patients than im administration.
Authors:
D L Mallory; J E Parrillo; K R Bailey; G L Akin; M Brenner; H C Lane; A S Fauci; H Masur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  15     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-05-26     Completed Date:  1987-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-5     Citation Subset:  AIM; IM; X    
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MeSH Terms
Descriptor/Qualifier:
Amidines / administration & dosage*
Hemodynamics / drug effects*
Humans
Infusions, Intravenous
Injections, Intramuscular / adverse effects*
Intensive Care Units
Necrosis / etiology
Pentamidine / administration & dosage*,  therapeutic use
Pneumonia, Pneumocystis / drug therapy
Skin / pathology
Chemical
Reg. No./Substance:
0/Amidines; 100-33-4/Pentamidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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