Document Detail

Cardiovascular effects of radioactive microsphere suspensions and Tween 80 solutions.
MedLine Citation:
PMID:  842689     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of two concentrations of Tween 80 (polyoxyethylene sorbitan mono-oleate), a surface-active agent commonly used to prevent aggregation of radionuclide-labeled microspheres, were examined in conscious dogs. Two types of adverse reactions were noted. The first (Type A) consisted of reductions in cardiac dimensions as well as hypotension and tachycardia. The second (Type B) was less severe and involved only a decrease in cardiac dimensions with no change in left ventricular systolic pressure or heart rate. A 10% dextran solution with .05 +/- .02% Tween 80 injected into the left atrium caused systemic and/or cardiac alterations in all four dogs studied. Administration of a lower concentration of Tween 80 (0.01 +/- 0.005%), which was the minimum concentration necessary to prevent aggregation of microspheres, induced adverse reactions in 6 of 41 dogs studied. Subsequent administration of this concentration of Tween 80 on the same day rarely induced adverse reactions. Thus, care must be exercised in application of microsphere techniques to organ blood flow measurements when Tween 80 is used to prevent microsphere aggregation, since this surface-active agent causes profound alterations in cardiac dynamics in concentrations normally employed in experiments involving microsphere techniques.
R W Millard; H Baig; S F Vatner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  232     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-04-30     Completed Date:  1977-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H331-4     Citation Subset:  IM; S    
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MeSH Terms
Cardiac Volume / drug effects
Coronary Circulation / drug effects
Dextrans / adverse effects,  pharmacology
Heart / drug effects
Heart Atria
Heart Rate / drug effects
Heart Ventricles / drug effects
Hemodynamics / drug effects*
Hypotension / chemically induced*
Polyethylene Glycols / adverse effects*
Polysorbates / adverse effects*,  pharmacology
Reg. No./Substance:
0/Polyethylene Glycols; 0/Polysorbates; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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