Document Detail

Cardiovascular effects of prostaglandin F(2 alpha) and prostaglandin E(2) in Atlantic cod (Gadus morhua).
MedLine Citation:
PMID:  12122452     Owner:  NLM     Status:  MEDLINE    
Little is known of the cardiovascular functions of prostaglandins in non-mammalian vertebrates. There are indications that prostaglandins may have a function in haemostasis by constricting blood vessels in filament arteries in the fish gill after injury. Our aim was to examine the cardiovascular effect of the prostaglandins F(2 alpha) (PGF(2 alpha)) and E(2) (PGE(2)) with emphasis on branchial circulation. Intra-arterial injections of PGF(2 alpha) (10, 40, 160, 400 nmol kg(-1)) in cod caused a dose-dependent increase in ventral aortic blood pressure, a reduction in cardiac output, and an increase in gill vascular resistance. A contraction of filament arteries was observed with in vivo microscopy only seconds after injection. PGF(2 alpha) may therefore possibly be involved in a haemostatic vasoconstriction. In contrast, the most significant effects of PGE(2) appeared to be on the heart. PGE(2) also reduced dorsal aortic blood pressure.
K-O Stensløkken; L Sundin; G E Nilsson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-05-03
Journal Detail:
Title:  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology     Volume:  172     ISSN:  0174-1578     ISO Abbreviation:  J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2003-02-03     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8413200     Medline TA:  J Comp Physiol B     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
Division of General Physiology, Department of Biology, University of Oslo, PO Box 1051, N-0316 Oslo, Norway.
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MeSH Terms
Dinoprost / pharmacology*,  physiology
Dinoprostone / pharmacology*,  physiology
Dose-Response Relationship, Drug
Gills / blood supply*
Hemostasis / physiology
Microcirculation / drug effects
Vasoconstriction / drug effects*
Reg. No./Substance:
363-24-6/Dinoprostone; 551-11-1/Dinoprost

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