Document Detail

Cardiovascular effects of prazosin in dogs.
MedLine Citation:
PMID:  1071689     Owner:  NLM     Status:  MEDLINE    
1. In pentobarbitone-anaesthetized dogs, prazosin (2 x 1-3 micronmol day-1 kg-1; 2 x 0-5 mg day-1 kg-1) administered orally for 3 days reduced resting aortic blood pressure as well as the pressor response to bilateral carotid occlusion. Prazosin neither affected resting heart rate nor the tachycardia induced by intravenous isoprenaline, noradrenaline and electrical stimulation of preganglionic and postganglionic sympathetic nerve fibres. Prazosin significantly attenuated the fall in perfusion pressure in a perfused hind leg resulting from the section of the ipsilateral sympathetic lumbar chain. Furthermore, the drug inhibited by about 50% the hind-leg pressor responses elicited by intra-arterial administration of alpha-adrenoreceptor agonists and by stimulation of the lumbar sympathetic chain, without altering the effects of angiotension II. 2. Acute administration of prazosin into the innervated hind leg provoked a dose-related reduction in vascular resistance. However, after spinal anaesthesia no such an effect was observed even when vascular tone was increased by infusion of vasopressin. Under the same experimental conditions administration of papaverine induced a vasodilatation. 3. This study confirms that prazosin impairs the function of vascular alpha-adrenoreceptors, and strongly challenges the claim that this compound produces a directly mediated vasodilatation of the leg vascular bed.
I Cavero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  3     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  609s-612s     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Heart / drug effects*
Heart Rate / drug effects
Hindlimb / blood supply
Prazosin / pharmacology*
Quinazolines / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Quinazolines; 19216-56-9/Prazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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