Document Detail

Cardiovascular effects of positive end-expiratory pressure (PEEP) after pneumonectomy in dogs.
MedLine Citation:
PMID:  3904649     Owner:  NLM     Status:  MEDLINE    
Little is known regarding the hemodynamic effect of positive end-expiratory pressure (PEEP) following pneumonectomy. To investigate this, 9 mongrel dogs underwent PEEP before and after lung resection. With the chest closed, the dog anesthetized, and partial pressure of carbon dioxide constant, PEEP was added in increments of 2 mm Hg until the animal's condition became hemodynamically unstable. At each level of PEEP, aortic, pulmonary, left atrial, and central venous pressures were monitored while aortic flow (cardiac output) was determined with an electromagnetic probe and airway pressure was measured with a Millar catheter in the respiratory tubing. Pneumonectomy was then performed, PEEP was again sequentially added, and the same measurements were recorded. Both before and after pneumonectomy, a strong positive linear correlation exists between the level of PEEP and pulmonary vascular resistance (PVR) (r greater than 0.74; p less than 0.05). Also, there is a high negative linear correlation between the level of PEEP and cardiac output (r greater than -0.76; p less than 0.05). At 0 mm Hg of PEEP, the PVR is higher after pneumonectomy than before (p less than 0.02). The incremental elevation in PVR persists after pneumonectomy at each level of PEEP, and in 5 of the 9 dogs the slope of the linear regression line relating PVR to PEEP was steeper following resection (p less than 0.05), thereby demonstrating an exaggerated effect of PEEP on PVR. In addition, all animals had a lower cardiac output at each comparable level of PEEP following pneumonectomy (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
M E Lores; B A Keagy; T Vassiliades; G W Henry; C L Lucas; B R Wilcox
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  40     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-20     Completed Date:  1985-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Cardiovascular Physiological Phenomena*
Central Venous Pressure
Lung Compliance
Positive-Pressure Respiration*
Pulmonary Artery
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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