Document Detail


Cardiovascular effects of a phosphodiesterase III inhibitor in the presence of carvedilol in dogs.
MedLine Citation:
PMID:  16820710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine whether dobutamine, dopamine, or milrinone (a phosphodiesterase [PDE] III inhibitor) would support cardiac function that had been attenuated by administration of the beta-blocker, carvedilol (0.2, 0.4, or 0.8 mg/kg). Hemodynamic and cardiac parameters including the heart rate (HR), left-ventricular fractional shortening (FS), and arterial pressure were measured in six healthy dogs without cardiac disease. Carvedilol did not affect FS or arterial pressure, but decreased the HR significantly. The positive inotropic and chronotropic responses to dobutamine and dopamine were attenuated by carvedilol, whereas arterial pressure was unaffected. Milrinone did not affect the HR and decreased arterial pressure, whereas FS was significantly greater both in the control and carvedilol-treated groups. Although milrinone affect the negative chronotropic effects of carvedilol, milrinone increased FS and prevented the decrease in arterial pressure. These results suggest that inhibition of PDE III preserves cardiac contractility and hemodynamic function in the presence of carvedilol.
Authors:
Masami Uechi; Yasutomo Hori; Keiko Fujimoto; Takashi Ebisawa; Shigeki Yamano; Shinnosuke Maekawa
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  68     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-07-05     Completed Date:  2006-08-22     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  549-53     Citation Subset:  IM    
Affiliation:
Veterinary Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University, Aomori, Japan.
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MeSH Terms
Descriptor/Qualifier:
3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
Adrenergic beta-Antagonists / pharmacology
Animals
Blood Pressure / drug effects
Carbazoles / pharmacology*
Cardiovascular Physiological Phenomena / drug effects*
Cyclic Nucleotide Phosphodiesterases, Type 3
Dobutamine / pharmacology*
Dogs*
Dopamine / pharmacology*
Drug Interactions
Female
Heart Rate / drug effects
Male
Milrinone / pharmacology*
Myocardial Contraction / drug effects
Propanolamines / pharmacology*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; 34368-04-2/Dobutamine; 78415-72-2/Milrinone; EC 3.1.4.17/3',5'-Cyclic-AMP Phosphodiesterases; EC 3.1.4.17/Cyclic Nucleotide Phosphodiesterases, Type 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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