| Cardiovascular effects of phenelzine and amitriptyline in depressed outpatients. | |
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MedLine Citation:
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PMID: 7042699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood pressure and ECG changes were monitored in depressed outpatients treated for 6 weeks with amitriptyline, 150 mg/day, or phenelzine, 60 mg/day, as part of an ongoing double-blind study. Phenelzine produced significant decreases in blood pressure and a significant increase in orthostatic fall in pressure. Amitriptyline produced little overall change in blood pressure. The degree of MAO inhibition in phenelzine-treated patients was significantly correlated with blood pressure. Tricyclic plasma concentrations were also related to some blood pressure measures. Reported dizziness/faintness did not correlate with blood pressure changes in either group. Amitriptyline significantly increased heart rate, while phenelzine produced slowing. Amitriptyline was associated with significant prolongation of QRS and QTc but not PR intervals. Phenelzine produced significant shortening of the QTc interval. |
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Authors:
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D S Robinson; A Nies; J Corcella; T B Cooper; C Spencer; R Keefover |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 43 ISSN: 0160-6689 ISO Abbreviation: J Clin Psychiatry Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-07-22 Completed Date: 1982-07-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8-15 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amitriptyline / adverse effects*, blood, therapeutic use Blood Platelets / enzymology Blood Pressure / drug effects Cardiovascular System / drug effects* Clinical Trials as Topic Depression / drug therapy* Double-Blind Method Electrocardiography Humans Hypotension, Orthostatic / chemically induced Middle Aged Monoamine Oxidase / blood Phenelzine / adverse effects*, blood, therapeutic use Posture |
| Grant Support | |
ID/Acronym/Agency:
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MH-15333/MH/NIMH NIH HHS; MH-27836/MH/NIMH NIH HHS; MH-32176/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-48-6/Amitriptyline; 51-71-8/Phenelzine; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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