Document Detail


Cardiovascular effects of phenelzine and amitriptyline in depressed outpatients.
MedLine Citation:
PMID:  7042699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure and ECG changes were monitored in depressed outpatients treated for 6 weeks with amitriptyline, 150 mg/day, or phenelzine, 60 mg/day, as part of an ongoing double-blind study. Phenelzine produced significant decreases in blood pressure and a significant increase in orthostatic fall in pressure. Amitriptyline produced little overall change in blood pressure. The degree of MAO inhibition in phenelzine-treated patients was significantly correlated with blood pressure. Tricyclic plasma concentrations were also related to some blood pressure measures. Reported dizziness/faintness did not correlate with blood pressure changes in either group. Amitriptyline significantly increased heart rate, while phenelzine produced slowing. Amitriptyline was associated with significant prolongation of QRS and QTc but not PR intervals. Phenelzine produced significant shortening of the QTc interval.
Authors:
D S Robinson; A Nies; J Corcella; T B Cooper; C Spencer; R Keefover
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  43     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-15     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amitriptyline / adverse effects*,  blood,  therapeutic use
Blood Platelets / enzymology
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Clinical Trials as Topic
Depression / drug therapy*
Double-Blind Method
Electrocardiography
Humans
Hypotension, Orthostatic / chemically induced
Middle Aged
Monoamine Oxidase / blood
Phenelzine / adverse effects*,  blood,  therapeutic use
Posture
Grant Support
ID/Acronym/Agency:
MH-15333/MH/NIMH NIH HHS; MH-27836/MH/NIMH NIH HHS; MH-32176/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
50-48-6/Amitriptyline; 51-71-8/Phenelzine; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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