Document Detail


Cardiovascular effects of a new positive inotropic agent, (-)-(R)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]-ethanol (TA-064) in the anesthetized dog and isolated guinea pig heart.
MedLine Citation:
PMID:  6150129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The positive inotropic effect of TA-064, (-)-(R)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol, was studied in the anesthetized dog and isolated guinea pig heart. An intravenous administration of TA-064 dose-dependently increased the cardiac contractile force with little effect on blood pressure in dogs. The positive inotropic activity of TA-064 was 1/100 that of isoproterenol and similar to that of dobutamine. This effect of TA-064 was stereospecific, and it was blocked by practolol. Thus TA-064 has beta 1-adrenoceptor agonistic action. The positive inotropic effect of TA-064 was more pronounced than the positive chronotropic effect, compared with those of isoproterenol. Similar effect of TA-064 was observed in the reserpinized dog and in the isolated perfused heart of the guinea pig as well. TA-064 administered intraduodenally at a dose of 0.1 mg/kg increased contractile force by 120% of the control, and the effect lasted for more than 150 min. TA-064 given in the femoral artery demonstrated a very weak vasodilating effect on the artery. TA-064 is an orally active, positive inotropic agent. The selective positive inotropic action of TA-064 may result from its beta 1-adrenoceptor agonistic property.
Authors:
T Nagao; T Ikeo; S Murata; M Sato; H Nakajima
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  35     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-12-26     Completed Date:  1984-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  415-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Anesthesia
Animals
Blood Pressure / drug effects
Cardiotonic Agents / pharmacology*
Dobutamine / pharmacology
Dogs
Ethanolamines / pharmacology*
Femur / blood supply
Guinea Pigs
Heart / drug effects*
Male
Myocardial Contraction / drug effects
Perfusion
Phenylephrine / pharmacology
Regional Blood Flow / drug effects
Reserpine / pharmacology
Stereoisomerism
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Cardiotonic Agents; 0/Ethanolamines; 34368-04-2/Dobutamine; 50-55-5/Reserpine; 59-42-7/Phenylephrine; 71771-90-9/denopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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