Document Detail

Cardiovascular effects of neurotensin and some analogues on rats.
MedLine Citation:
PMID:  2323349     Owner:  NLM     Status:  MEDLINE    
When administered in vivo into the femoral vein of normotensive rats, neurotensin, neurotensin-(8-13), and [D-Lys8]neurotensin-(8-13) decreased diastolic blood pressure in a dose-dependent manner, without change in heart rate. All three peptides evoked tachyphylaxis and a triphasic depressor-pressor-depressor, response at higher doses. The rank order of potency was neurotensin greater than [D-Lys8]neurotensin-(8-13) greater than neurotensin-(8-13). In organ chamber experiments, both neurotensin and neurotensin-(8-13) at a range of concentrations which induced dose-dependent decreases in blood pressure, did not significantly change tension in rat aorta rings with or without endothelium. In contrast, [D-Lys8]neurotensin-(8-13) induced weak dose-dependent relaxation of both rings with or without endothelium. However, this effect was not obtained at concentrations able to decrease the blood pressure. Indomethacin did not change the vasodilator effect of [D-Lys8]neurotensin-(8-13). There was no correlation between the vasodilator effect of this peptide and its ability to decrease blood pressure. These experiments suggest that the hypotension was not due to a direct vasodilator effect on the smooth muscle. In addition, since the rank order of peptide potency was opposite of those found in previous studies of second messenger synthesis and binding to neural tissue, these data suggest that there is a second receptor for neurotensin or that neurotensin can also bind to a different unknown receptor.
E D Di Paola; E Richelson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  175     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-05-15     Completed Date:  1990-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  279-83     Citation Subset:  IM    
Department of Psychiatry, Mayo Foundation, Rochester, MN 55905.
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MeSH Terms
Aorta, Thoracic / drug effects
Blood Pressure / drug effects
Hemodynamics / drug effects*
Muscle, Smooth, Vascular / drug effects
Neurotensin / analogs & derivatives,  pharmacology*
Peptide Fragments / pharmacology
Structure-Activity Relationship
Vasodilation / drug effects*
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 39379-15-2/Neurotensin; 60482-95-3/neurotensin (8-13)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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