Document Detail

Cardiovascular effects of i.v. induction in children: comparison between propofol and thiopentone.
MedLine Citation:
PMID:  8329259     Owner:  NLM     Status:  MEDLINE    
We have compared the haemodynamic responses to i.v. propofol 2.5 mg kg-1 with those to thiopentone 5.0 mg kg-1 in 41 healthy Chinese children at induction of anaesthesia. They were allocated to four groups according to their age and induction agent received: group 1 < 2 yr, propofol, n = 9; group II < 2 yr, thiopentone, n = 9; group III 2-12 yr, propofol, n = 12; group IV 2-12 yr, thiopentone, n = 11. Anaesthesia was maintained by spontaneous ventilation with 70% nitrous oxide and 0.5% halothane in oxygen. Arterial pressure and heart rate were monitored by automatic oscillotonometer. Stroke volume was measured by two-dimensional echocardiography and pulse Doppler. Measurements were made before induction and at 1-min intervals for 5 min after induction. The reduction in mean arterial pressure was significantly greater after propofol (28-31%) than after thiopentone (14-21%) (P = 0.001). The reduction in cardiac index (10-15%) after induction was not significantly different between the two agents (P = 0.122). Baroreflex mediated increases in heart rate and systemic vascular resistance were less after propofol than after thiopentone. The baroreceptor reflex was more attenuated in children aged less than 2 yr than in older children.
C S Aun; R Y Sung; M E O'Meara; T G Short; T E Oh
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  70     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-17     Completed Date:  1993-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  647-53     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories.
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MeSH Terms
Anesthesia, Inhalation
Anesthesia, Intravenous*
Blood Pressure / drug effects
Child, Preschool
Double-Blind Method
Heart Rate / drug effects
Hemodynamics / drug effects*
Propofol / pharmacology*
Stroke Volume / drug effects
Thiopental / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
2078-54-8/Propofol; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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