| Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess. | |
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MedLine Citation:
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PMID: 20118410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the role of the renin-angiotensin-aldosterone system (RAAS) in mediating cardiovascular and renal damage in spontaneously hypertensive rats (SHR) given salt excess. Since the circulating RAAS is inhibited in this model, it permits examination of the role of local tissue RAASs in mediating this injury. To this end, male 8-wk SHR were divided into 7 groups. The control group (C) received normal NaCl (0.6%) diet. All other groups were given 8% NaCl chow. In addition, group 2 was given placebo, group 3 the mineralocorticoid receptor blocker eplerenone (100 mg.kg(-1).day(-1)), group 4 the angiotensin converting enzyme inhibitor quinapril (3 mg.kg(-1).day(-1)), group 5 the angiotensin II type 1 receptor blocker candesartan (10 mg.kg(-1).day(-1)), and groups 6 and 7 eplerenone and either quinapril or candesartan. The treatments lasted 8 wk. Compared with controls, mean arterial pressure (MAP), renal blood flow, coronary flow reserve, minimal coronary vascular resistance, diastolic time constant, and maximal rate of ventricular pressure fall were all adversely affected by salt loading. Left ventricular mass and fibrosis as well as proteinuria were also markedly increased by salt overload. Eplerenone induced only slight changes, whereas quinapril and candesartan normalized all indexes except MAP. Combination therapy also normalized all indexes, including MAP. These data suggest that 1) cardiovascular and renal damage induced by salt excess in the SHR were not pressure dependent; 2) mineralocorticoids were only marginally involved in this model; and 3) local tissue generation of angiotensin II may be, at least in part, responsible for the other adverse effects. |
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Authors:
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Dinko Susic; Jasmina Varagic; Edward D Frohlich |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-29 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 298 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1177-81 Citation Subset: IM |
Affiliation:
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Ochsner Clinic Foundation, New Orleans, LA 70121, USA. dsusic@ochsner.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II Type 1 Receptor Blockers
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pharmacology* Angiotensin-Converting Enzyme Inhibitors / pharmacology* Animals Benzimidazoles / pharmacology Blood Pressure / drug effects Cardiomyopathies / chemically induced, pathology Cardiovascular System / drug effects, physiopathology* Hypertension / physiopathology* Hypertrophy / chemically induced, pathology Kidney / blood supply Male Rats Rats, Inbred SHR Receptors, Mineralocorticoid / antagonists & inhibitors, drug effects Regional Blood Flow / drug effects Renin-Angiotensin System / drug effects*, physiology* Sodium Chloride, Dietary / adverse effects, pharmacology* Spironolactone / analogs & derivatives, pharmacology Tetrahydroisoquinolines / pharmacology Tetrazoles / pharmacology Ventricular Dysfunction, Left / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzimidazoles; 0/Receptors, Mineralocorticoid; 0/Sodium Chloride, Dietary; 0/Tetrahydroisoquinolines; 0/Tetrazoles; 0/eplerenone; 139481-59-7/candesartan; 52-01-7/Spironolactone; 82586-55-8/quinapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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