Document Detail

Cardiovascular effects of inhalation induction with isoflurane in infants.
MedLine Citation:
PMID:  6829944     Owner:  NLM     Status:  MEDLINE    
We evaluated hemodynamic changes during inhalation induction of isoflurane anesthesia in 60 healthy infants aged 5-26 weeks who were randomly divided into two groups of 30 patients each. In group 1 anesthesia was induced using isoflurane in concentrations that were increased to 3.5%. In group 2, 0.02 mg/kg of atropine was given intramuscularly before induction of anesthesia, as in group 1. In both groups, N2O (3 L/min) and O2 (2 L/min) were administered using a nonrebreathing system. Heart rate (HR) and blood pressure (BP) were recorded at 1-min intervals for 20 min. HR decreased 32% in group 1 and 20% in group 2; BP decreased 40% in group 1 and 38% in group 2. During isoflurane induction in infants, both HR and BP are depressed. Premedication with atropine minimizes the depression of HR, but does not affect the change in BP.
R H Friesen; J L Lichtor
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  62     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-4     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation*
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Heart Rate / drug effects
Isoflurane / pharmacology*
Laryngismus / chemically induced
Methyl Ethers / pharmacology*
Reg. No./Substance:
0/Methyl Ethers; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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