Document Detail

Cardiovascular effects of hyperhomocysteinemia in conscious unrestrained rats.
MedLine Citation:
PMID:  16461198     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Experiments were designed to determine whether hyperhomocysteinemia (Hhe) affects cardiovascular function when monitored in conscious unrestrained animals. METHODS: Adult, male Sprague-Dawley rats were fed a homocystine-supplemented diet for 6 months. Blood pressure (BP), heart rate, and pulse pressure were monitored continuously, 24 h a day, using biotelemetry techniques. RESULTS: The resulting intermediate level of Hhe was not associated with significant changes in heart rate, diastolic BP, systolic BP, or the circadian variation in heart rate. In spite of the lack of significant changes in systolic and diastolic BP, there was a slight but statistically significant increase in pulse pressure after 4 months of treatment that returned toward control levels after 6 months. CONCLUSIONS: Current results indicate that Hhe alone does not have significant effects on BP. Furthermore, they suggest that the previously reported Hhe-induced adverse cardiac remodeling and diastolic dysfunction in this animal model are not the result of pressure overload.
Richard H Kennedy; Russell B Melchert; Jacob Joseph
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  19     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-05-11     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Cardiovascular System / physiopathology*
Data Interpretation, Statistical
Heart Rate / drug effects
Homocystine / administration & dosage
Hyperhomocysteinemia / physiopathology*
Rats, Sprague-Dawley
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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