| Cardiovascular effects of gastric intubation and distension in healthy humans. | |
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MedLine Citation:
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PMID: 18004986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few data exist on the effect of upper gut stimuli on the cardiovascular system. Aim of our study was to evaluate the cardiovascular effects of gastric intubation and distension. Eleven healthy subjects (eight men, aged 21-30 years) were studied and a non-invasive beat-to-beat cardiovascular monitoring system was used. After 15-min basal recording, a bag catheter was positioned in the proximal stomach and connected to a barostat. Recordings were first performed for 15 min with the bag deflated, then during inflation of air using a 100 mL per 2 min stepwise protocol until epigastric discomfort was reported, and finally for 15 min with the bag inflated at 75% of discomfort volume spared from the preceding period by 10 min with the bag deflated. Presence of the deflated bag catheter significantly increased mean arterial pressure. Stepwise distension progressively increased heart rate and cardiac index, while mean arterial pressure was affected only at discomfort volume. Peripheral resistances and systemic plasma catecholamines were unaffected. During prolonged distension, the effect on heart rate and cardiac index was transient. In conclusion, both gastric intubation and distension alter cardiovascular parameters, but the effect of distension undergoes rapid adaptation. Experimentally induced gastric distension is a valuable stimulus to study viscero-cardiovascular reflexes and their mechanisms using beat-to-beat measurements. |
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Authors:
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P Cantù; D Savojardo; M V Barelli; V Buonamici; G Bertinieri; R Penagini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-14 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 20 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-28 Completed Date: 2008-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 304-10 Citation Subset: IM |
Affiliation:
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Cattedra di Gastroenterologia, Dipartimento di Scienze Mediche, University of Milan, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology* Dilatation, Pathologic / complications*, physiopathology Female Heart / physiology* Heart Rate / physiology* Humans Intubation, Gastrointestinal / adverse effects* Male Manometry |
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