| Cardiovascular effects of the fungal extract of basidiomycetes sp. YL8006. | |
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MedLine Citation:
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PMID: 9180352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many fungal products are known to possess biological activity towards the mammalian tissues. We studied vasodilating activity in the crude ethanol extract of the dried mycelia of Basidiomycetes sp. YL8006, cultured by submerged fermentation with a complex medium. The activity was assayed using the isolated perfused rat heart in the working mode. Immediately following injection of the extract into the perfusion system, a 20-25% increase in coronary flow was observed (p<0.001 vs. solvent vehicle control). There was a concurrent decrease in diastolic pressure and coronary vascular resistance. Aortic flow, systolic pressure, and cardiac output declined slightly over time after treatment. No significant changes in heart rate, efficiency, and oxygen consumption were observed. Solvent vehicle did not cause any changes in hemodynamic performance. |
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Authors:
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A S Andreacchi; T Wang; J H Wu |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 60 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-06-27 Completed Date: 1997-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1987-94 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering; University of Rochester, New York 14627, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basidiomycota / chemistry* Cardiovascular Agents / isolation & purification, pharmacology* Chromatography, High Pressure Liquid Hemodynamics / drug effects Male Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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5T32HL07216-17/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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