Document Detail

Cardiovascular effects of enoximone in isoflurane anaesthetized ponies.
MedLine Citation:
PMID:  17696974     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Enoximone is a phosphodiesterase III inhibitor frequently used to improve cardiac output (CO) in man. As the use of enoximone has not been reported in horses, the effects of this inodilator were examined in isoflurane anaesthetized ponies. STUDY DESIGN: Prospective, randomised, experimental study. ANIMALS: Six healthy ponies, weighing 286 (212-367) +/- 52 kg, aged 5.0 +/- 1.6 years (4-6.5). METHODS: After sedation with romifidine [80 microg kg(-1) intravenously (IV)], general anaesthesia was induced with midazolam (0.06 mg kg(-1) IV) and ketamine (2.2 mg kg(-1) IV) and maintained with isoflurane in oxygen (Et Iso 1.7%). The ponies were ventilated to maintain eucapnia (PaCO(2) 4.66-6.00 kPa). Each pony was anaesthetized twice with an interval of 3 weeks; receiving enoximone 0.5 mg kg(-1) IV (E) or saline (S) 90 minutes post-induction. Heart rate (HR), arterial (AP) and right atrial pressure (RAP) were measured before treatment, every 5 minutes between T0 (treatment) and T30 and then every 10 minutes until T120. Cardiac output measurements (lithium dilution technique) and blood gas analysis (arterial and central venous samples) were performed before T0 and at T5, T10, T20, T40, T60, T80, T100 and T120. Stroke volume (SV), systemic vascular resistance (SVR), venous admixture (Qs/Qt) and oxygen delivery (DO(2)) were calculated. RESULTS: Enoximone induced significant increases in HR, CO, SV, Qs/Qt and DO(2) and a significant decrease in RAP. No significant differences were detected for AP, SVR and blood gases. No cardiac arrhythmias or other side effects were observed. CONCLUSIONS AND CLINICAL RELEVANCE: The present results suggest that in isoflurane anaesthetized ponies, enoximone has beneficial effects on CO and SV without producing significant changes in blood pressure. Despite an increase in Qs/Qt, DO(2) to the tissues was improved.
Stijn Schauvliege; Annelies Van den Eede; Luc Duchateau; Frank Gasthuys
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-08-13
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  34     ISSN:  1467-2987     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  416-30     Citation Subset:  IM    
Department Of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium.
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MeSH Terms
Anesthesia / veterinary*
Anesthetics, Inhalation / administration & dosage,  pharmacology
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects*
Cardiotonic Agents / administration & dosage,  pharmacology*
Enoximone / administration & dosage,  pharmacology*
Heart Rate / drug effects*
Horses / physiology*
Injections, Intravenous / veterinary
Isoflurane / administration & dosage,  pharmacology
Oxygen / blood
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Cardiotonic Agents; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 77671-31-9/Enoximone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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