Document Detail


Cardiovascular effects of enoximone in isoflurane anaesthetized ponies.
MedLine Citation:
PMID:  17696974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Enoximone is a phosphodiesterase III inhibitor frequently used to improve cardiac output (CO) in man. As the use of enoximone has not been reported in horses, the effects of this inodilator were examined in isoflurane anaesthetized ponies. STUDY DESIGN: Prospective, randomised, experimental study. ANIMALS: Six healthy ponies, weighing 286 (212-367) +/- 52 kg, aged 5.0 +/- 1.6 years (4-6.5). METHODS: After sedation with romifidine [80 microg kg(-1) intravenously (IV)], general anaesthesia was induced with midazolam (0.06 mg kg(-1) IV) and ketamine (2.2 mg kg(-1) IV) and maintained with isoflurane in oxygen (Et Iso 1.7%). The ponies were ventilated to maintain eucapnia (PaCO(2) 4.66-6.00 kPa). Each pony was anaesthetized twice with an interval of 3 weeks; receiving enoximone 0.5 mg kg(-1) IV (E) or saline (S) 90 minutes post-induction. Heart rate (HR), arterial (AP) and right atrial pressure (RAP) were measured before treatment, every 5 minutes between T0 (treatment) and T30 and then every 10 minutes until T120. Cardiac output measurements (lithium dilution technique) and blood gas analysis (arterial and central venous samples) were performed before T0 and at T5, T10, T20, T40, T60, T80, T100 and T120. Stroke volume (SV), systemic vascular resistance (SVR), venous admixture (Qs/Qt) and oxygen delivery (DO(2)) were calculated. RESULTS: Enoximone induced significant increases in HR, CO, SV, Qs/Qt and DO(2) and a significant decrease in RAP. No significant differences were detected for AP, SVR and blood gases. No cardiac arrhythmias or other side effects were observed. CONCLUSIONS AND CLINICAL RELEVANCE: The present results suggest that in isoflurane anaesthetized ponies, enoximone has beneficial effects on CO and SV without producing significant changes in blood pressure. Despite an increase in Qs/Qt, DO(2) to the tissues was improved.
Authors:
Stijn Schauvliege; Annelies Van den Eede; Luc Duchateau; Frank Gasthuys
Related Documents :
16842774 - In vivo versus in vitro comparison of swine cardiac performance: induction of cardiodep...
1103914 - Positive end-expiratory pressure in anaesthetized spontaneously breathing horses.
8330594 - Effect of isoflurane and halothane on regional cardiac stiffness.
17451494 - Plasma colloid osmotic pressure and total protein trends in horses during anesthesia.
7091344 - Effects of increased venous pressure on albumin- and igg-excluded volumes in muscle.
23670354 - Aliskiren improves vascular smooth muscle function in the skin microcirculation of type...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-08-13
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  34     ISSN:  1467-2987     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  416-30     Citation Subset:  IM    
Affiliation:
Department Of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium. stijn.schauvliege@ugent.be
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthesia / veterinary*
Anesthetics, Inhalation / administration & dosage,  pharmacology
Animals
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects*
Cardiotonic Agents / administration & dosage,  pharmacology*
Enoximone / administration & dosage,  pharmacology*
Female
Heart Rate / drug effects*
Horses / physiology*
Injections, Intravenous / veterinary
Isoflurane / administration & dosage,  pharmacology
Male
Oxygen / blood
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Cardiotonic Agents; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 77671-31-9/Enoximone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical evaluation of the Surgivet V60046, a non invasive blood pressure monitor in anaesthetized d...
Next Document:  Plasma colloid osmotic pressure and total protein in horses during colic surgery.