| Cardiovascular effects of endothelin in dogs: positive inotropic action in vivo. | |
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MedLine Citation:
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PMID: 2680523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endothelin, administered i.v. to anesthetized dogs, dose dependently increased the cardiac output, left ventricular systolic pressure (LVSP), and maximum upstroke velocity (max dp/dt) of the LVSP for about 10 min without changing the heart rate. Thereafter the cardiac output decreased to below the control level but max dp/dt decreased to the control level. The arterial pressure and total peripheral resistance showed an initial, transient decrease followed by a sustained increase. These results suggest that endothelin has positive inotropic and long-lasting vasoconstrictive effects preceded by transient vasodilatation in vivo. |
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Authors:
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T Kitayoshi; T Watanabe; N Shimamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 166 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-11-27 Completed Date: 1989-11-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 519-22 Citation Subset: IM |
Affiliation:
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Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Blood Pressure / drug effects Cardiac Output / drug effects Dogs Dose-Response Relationship, Drug Endothelins Female Hemodynamics / drug effects* Male Myocardial Contraction / drug effects* Peptides / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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