| Cardiovascular effects of dopamine in the normal and failing heart of experimental animals. | |
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MedLine Citation:
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PMID: 1197888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dopamine exerts marked positive inotropic effects in the dog with no effect on heart rate. This effect is abolished by propranolol, reduced by reserpine, and unaffected by atropine. Dopamine exhibits similar inotropic activity in the normal guinea pig and in guinea pigs with experimentally induced heart failure. In the isolated perfused hamster heart, dopamine caused marked increases in left ventricular pressure with slight increases in heart rate. However, in the failing heart of the myopathic Syrian hamster, dopamine caused moderate increases in left ventricular pressure with much greater increases in heart rate. The total heart work of the failing heart under the influence of dopamine is significantly higher than that of the normal heart. The energy utilization under this condition is equal in both hearts. Therefore, the calculated efficiency of the failing heart treated with dopamine is much higher than that of the normal heart treated similarly. |
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Authors:
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A A Alousi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Recent advances in studies on cardiac structure and metabolism Volume: 6 ISSN: 0363-5872 ISO Abbreviation: Recent Adv Stud Cardiac Struct Metab Publication Date: 1975 |
Date Detail:
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Created Date: 1976-02-27 Completed Date: 1976-02-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0325677 Medline TA: Recent Adv Stud Cardiac Struct Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-300 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Blood Pressure / drug effects Cricetinae Dogs Dopamine / pharmacology, therapeutic use* Dopamine Antagonists Female Guinea Pigs Heart Failure / drug therapy* Heart Rate / drug effects Male Monoamine Oxidase Inhibitors Myocardial Contraction / drug effects Pargyline / pharmacology Propranolol / pharmacology Reserpine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 0/Monoamine Oxidase Inhibitors; 50-55-5/Reserpine; 51-55-8/Atropine; 525-66-6/Propranolol; 555-57-7/Pargyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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