Document Detail

Cardiovascular effects of dopamine in the normal and failing heart of experimental animals.
MedLine Citation:
PMID:  1197888     Owner:  NLM     Status:  MEDLINE    
Dopamine exerts marked positive inotropic effects in the dog with no effect on heart rate. This effect is abolished by propranolol, reduced by reserpine, and unaffected by atropine. Dopamine exhibits similar inotropic activity in the normal guinea pig and in guinea pigs with experimentally induced heart failure. In the isolated perfused hamster heart, dopamine caused marked increases in left ventricular pressure with slight increases in heart rate. However, in the failing heart of the myopathic Syrian hamster, dopamine caused moderate increases in left ventricular pressure with much greater increases in heart rate. The total heart work of the failing heart under the influence of dopamine is significantly higher than that of the normal heart. The energy utilization under this condition is equal in both hearts. Therefore, the calculated efficiency of the failing heart treated with dopamine is much higher than that of the normal heart treated similarly.
A A Alousi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  6     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-27     Completed Date:  1976-02-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Blood Pressure / drug effects
Dopamine / pharmacology,  therapeutic use*
Dopamine Antagonists
Guinea Pigs
Heart Failure / drug therapy*
Heart Rate / drug effects
Monoamine Oxidase Inhibitors
Myocardial Contraction / drug effects
Pargyline / pharmacology
Propranolol / pharmacology
Reserpine / pharmacology
Reg. No./Substance:
0/Dopamine Antagonists; 0/Monoamine Oxidase Inhibitors; 50-55-5/Reserpine; 51-55-8/Atropine; 525-66-6/Propranolol; 555-57-7/Pargyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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