Document Detail

Cardiovascular effects of desipramine in children and adults during exercise testing.
MedLine Citation:
PMID:  9951217     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In light of recent reports of sudden death in children being treated with desipramine (DMI), 3 of which were associated with physical exercise, the authors examined the effects of DMI on exercise in children and adults before and during DMI treatment. METHOD: Before treatment, 22 subjects (9 children, 13 adults) participated in a graded treadmill exercise test. Outcome measures included exercise tolerance, cardiovascular, and electrocardiographic parameters at progressive intensity levels and serum norepinephrine (NE) levels before and after exercise testing. Subjects were then treated with DMI, titrated to an average DMI dosage of 3 mg/kg, and underwent repeated exercise testing. RESULTS: DMI treatment was associated with a significant elevation of circulating NE levels in the pre-exercise assessment. Exercise tolerance was not affected by DMI, and blood pressure and heart rate effects were modest. The cardiovascular impact of DMI treatment was similar in children and adults. One 31-year-old subject exhibited a brief episode of ventricular tachycardia associated with exercise during DMI treatment. CONCLUSIONS: DMI has only minor effects on the cardiovascular response to exercise, and these effects do not appear age-related. However, DMI may increase the risk of exercise-associated arrhythmias in rare individuals.
B D Waslick; B T Walsh; L L Greenhill; E G Giardina; R P Sloan; J T Bigger; K Bilich
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Academy of Child and Adolescent Psychiatry     Volume:  38     ISSN:  0890-8567     ISO Abbreviation:  J Am Acad Child Adolesc Psychiatry     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-23     Completed Date:  1999-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8704565     Medline TA:  J Am Acad Child Adolesc Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York 10032, USA.
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MeSH Terms
Age Factors
Antidepressive Agents, Tricyclic / adverse effects,  pharmacology*
Arrhythmias, Cardiac / etiology
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Depression / prevention & control*
Desipramine / adverse effects,  pharmacology*
Exercise Test / drug effects*
Exercise Tolerance / drug effects
Heart Rate / drug effects
Norepinephrine / blood
Grant Support
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 50-47-5/Desipramine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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