Document Detail


Cardiovascular effects of befunolol, betaxolol and timolol eye drops.
MedLine Citation:
PMID:  1977708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double-blind cross-over study was carried out on 15 glaucoma patients so as to verify the effects of three the beta blockers, beta-1 selective betaxolol, non-selective timolol and befunolol an agent with intrinsic sympathomimetic activity on the heart rate, monitored by a Holter apparatus, and with the blood pressure measured in standing and supine positions before and after eight days of topical therapy. The results showed that timolol induced a significant decrease in minimum heart rate (-4.2 +/- 2.9) (p less than 0.001) and in diastolic blood pressure in standing position (-8.0 +/- 12.5 mmHg) (p less than 0.05), betaxolol decreased systolic pressure in orthostatism (-7.5 +/- 12.3 mmHg) and in clinostatism (-12.1 +/- 16.2 mmHg) and diastolic pressure in orthostatism (-6.25 +/- 9.4 mmHg) (p less than 0.05). Befunolol alone did not alter the heart rate or blood pressure.
Authors:
M T Dorigo; O Cerin; G Fracasso; R Altafini
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  10     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-04     Completed Date:  1990-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Affiliation:
University Eye Clinic, Padua, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*,  therapeutic use
Betaxolol / pharmacology*,  therapeutic use
Blood Pressure / drug effects*
Double-Blind Method
Electrocardiography
Female
Glaucoma / drug therapy
Heart Rate / drug effects*
Humans
Male
Middle Aged
Propanolamines / pharmacology*,  therapeutic use
Timolol / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 26839-75-8/Timolol; 39552-01-7/befunolol; 63659-18-7/Betaxolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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