| Cardiovascular effects of befunolol, betaxolol and timolol eye drops. | |
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MedLine Citation:
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PMID: 1977708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind cross-over study was carried out on 15 glaucoma patients so as to verify the effects of three the beta blockers, beta-1 selective betaxolol, non-selective timolol and befunolol an agent with intrinsic sympathomimetic activity on the heart rate, monitored by a Holter apparatus, and with the blood pressure measured in standing and supine positions before and after eight days of topical therapy. The results showed that timolol induced a significant decrease in minimum heart rate (-4.2 +/- 2.9) (p less than 0.001) and in diastolic blood pressure in standing position (-8.0 +/- 12.5 mmHg) (p less than 0.05), betaxolol decreased systolic pressure in orthostatism (-7.5 +/- 12.3 mmHg) and in clinostatism (-12.1 +/- 16.2 mmHg) and diastolic pressure in orthostatism (-6.25 +/- 9.4 mmHg) (p less than 0.05). Befunolol alone did not alter the heart rate or blood pressure. |
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Authors:
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M T Dorigo; O Cerin; G Fracasso; R Altafini |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 10 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 1990 |
Date Detail:
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Created Date: 1990-12-04 Completed Date: 1990-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 163-6 Citation Subset: IM |
Affiliation:
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University Eye Clinic, Padua, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology*,
therapeutic use Betaxolol / pharmacology*, therapeutic use Blood Pressure / drug effects* Double-Blind Method Electrocardiography Female Glaucoma / drug therapy Heart Rate / drug effects* Humans Male Middle Aged Propanolamines / pharmacology*, therapeutic use Timolol / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 26839-75-8/Timolol; 39552-01-7/befunolol; 63659-18-7/Betaxolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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