Document Detail

Cardiovascular effects of amitriptyline in the treatment of elderly depressed patients.
MedLine Citation:
PMID:  3931149     Owner:  NLM     Status:  MEDLINE    
Thirteen elderly depressed patients (age 60-82 years) were treated for 5 weeks with a fixed dose of amitriptyline 100 mg (sustained release preparation). In all patients the sum of concentrations of amitriptyline and nortriptyline exceeded 130 micrograms/l, which is the recommended plasma level. Cardiovascular side effects were recorded by monitoring heart rate, blood pressure, standard ECG and systolic time intervals. During treatment, a transient increase in the supine heart rate was observed without significant changes in the supine blood pressure. The orthostatic drop in blood pressure was markedly increased during treatment without a compensatory increase in heart rate, and these changes remained significant during the whole investigational period. PQ and QRS were significantly increased during treatment, and significant changes in the systolic time intervals were found indicating impairment of myocardial conduction and contractility. In three patients medication was discontinued due to cardiovascular side effects.
P Christensen; H Y Thomsen; O L Pedersen; P Thayssen; H Oxhøj; P Kragh-Sørensen; L F Gram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  87     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-19     Completed Date:  1985-11-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  212-5     Citation Subset:  IM    
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MeSH Terms
Amitriptyline / adverse effects*,  therapeutic use
Blood Pressure / drug effects
Delayed-Action Preparations
Depressive Disorder / drug therapy*,  physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Delayed-Action Preparations; 50-48-6/Amitriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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