Document Detail

Cardiovascular effects of the alpha2-adrenergic receptor agonist medetomidine in clinically normal cats anesthetized with isoflurane.
MedLine Citation:
PMID:  9563639     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the cardiovascular effects of the alpha2-adrenergic receptor agonist medetomidine in healthy cats anesthetized with 2% isoflurane. ANIMALS: 11 clinically normal cats. PROCEDURE: Cats were anesthetized with isoflurane, and catheters were inserted for measurement of aortic, left ventricular, and right atrial pressures. For data collection, end-tidal isoflurane concentration was reduced to 2%, and end-tidal CO2 was maintained at 35 to 40 mm of Hg by use of positive-pressure ventilation. After measurement of baseline data, medetomidine (0.01 mg/kg of body weight, i.m.) was administered and data were collected continuously for 75 minutes. At the end of data collection, incisions were closed and cats were allowed to recover from anesthesia. RESULTS: Medetomidine significantly increased mean arterial pressure and systemic vascular resistance. The increase in mean arterial pressure was maximal at 17.8 +/- 7 minutes after medetomidine administration. Medetomidine also increased left ventricular peak systolic pressure, left ventricular end diastolic pressure, and right atrial pressure. Medetomidine significantly decreased heart rate and mean aortic flow. CONCLUSIONS: The low dosage of medetomidine (0.01 mg/kg, i.m.) promoted severe vasoconstriction in isoflurane-anesthetized cats, and resulted in sustained increases in left ventricular preload and afterload.
A L Golden; J M Bright; G B Daniel; D Fefee; D Schmidt; R C Harvey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  59     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-02     Completed Date:  1998-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Department of Biological Sciences, Kennesaw State University, GA 30144-5591, USA.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Anesthesia, Inhalation*
Aorta / drug effects,  physiology
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Electrocardiography / drug effects
Hemodynamics / drug effects*,  physiology
Imidazoles / pharmacology*
Receptors, Adrenergic, alpha-2 / physiology*
Time Factors
Vascular Resistance / drug effects
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Imidazoles; 0/Receptors, Adrenergic, alpha-2; 26675-46-7/Isoflurane; 86347-14-0/Medetomidine

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