Document Detail

Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats.
MedLine Citation:
PMID:  24969105     Owner:  NLM     Status:  Publisher    
Treatment with antipsychotics is associated with adverse cardiovascular effects such as orthostatic hypotension and arrhythmias. Despite the higher prevalence of cardiovascular complications in patients with schizophrenia, the effects of antipsychotic drugs on vascular tone and cardiac contractility have received little attention. In order to better understand the cardiovascular effects of antipsychotic drugs, we investigated if the atypical antipsychotic olanzapine alters in vivo cardiovascular function in rats. Male Sprague-Dawley rats were prepared with indwelling catheters. After 4hours of recovery from surgery, mean arterial pressure (MAP), mean circulatory filling pressure (MCFP; index of body venous tone), heart rate, left ventricular peak systolic pressure (LVP) and cardiac contractility (±dP/dt) were measured in conscious, unrestrained rats at baseline for 60minutes after a single injection of olanzapine (3 or 15mg/kg, i.p.) or vehicle. Cardiovascular measurements were not altered at any time points in the vehicle-treated rats. Olanzapine did not affect heart rate, but dose-dependently decreased MAP, MCFP, LVP and+dP/dt, with maximal effects at 30minutes. Acute olanzapine treatment in rats thus reduced MAP and venous tone, as well as cardiac contractile function. Decreased venous tone may be a contributing factor to orthostatic hypotension commonly observed in patients during initiation of antipsychotic therapy.
Joanne Y T Leung; Catherine C Y Pang; Ric M Procyshyn; Alasdair M Barr
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-23
Journal Detail:
Title:  Vascular pharmacology     Volume:  -     ISSN:  1879-3649     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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