Document Detail

Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings.
MedLine Citation:
PMID:  18958835     Owner:  NLM     Status:  MEDLINE    
High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.
Antonio Ceriello
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease     Volume:  5     ISSN:  1479-1641     ISO Abbreviation:  -     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234011     Medline TA:  Diab Vasc Dis Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  260-8     Citation Subset:  IM    
Warwick Medical School, Clinical Science Research Institute, University Hospital -Coventry, CV2 2DX, UK.
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MeSH Terms
Acute Disease
Blood Glucose / metabolism
Cardiovascular Diseases / etiology*,  metabolism,  mortality,  pathology,  physiopathology
Hyperglycemia / complications*,  drug therapy,  metabolism,  mortality,  physiopathology
Hypertriglyceridemia / complications
Hypoglycemic Agents / therapeutic use
Myocardial Infarction / complications*,  metabolism,  mortality,  physiopathology
Oxidative Stress
Risk Factors
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents

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